Department of Cardiology, Wuxi NO. 2 People's Hospital, Nanjing Medical University, Wuxi 214000, Jiangsu, China.
Cardiol Young. 2023 Sep;33(9):1581-1586. doi: 10.1017/S1047951122002827. Epub 2022 Sep 6.
After patent foramen ovale interventional closure, puncture of the interatrial septum through the occluder is difficult but sometimes needed for further interventional treatment. This paper presents findings from an in vivo experimental study of a reserved atrial septal puncture area patent foramen ovale occluder.
A patent foramen ovale model was established in canines using trans-septal puncture of the fossa ovale and high-pressure balloon dilation. Then, patent foramen ovale closure was performed with a reserved atrial septal puncture area and all canines were raised for 3 months. Then, the occluder was crossed and left atrial angiography was performed on the septal area with the occluder. Finally, DSA angiography, echocardiography, and histology were used to evaluate the performance and feasibility of the reserved atrial septal puncture area.
A patent foramen ovale model was successfully established in 10 canines using the atrial septal puncture method. The average diameter of the patent foramen ovale was 3.77 ±0.19 mm, and the patent foramen ovale was successfully closed in all canines using a reserved atrial septal puncture area. As assessed using transoesophageal echocardiography, the new occluder exhibited an ideal position and was occluded entirely without a residual shunt intraoperatively and postoperatively. A 100% success rate of atrial septum puncture was achieved across the new occluder. The occluders were completely endothelialised 3 months post-implantation.
The reserved atrial septal puncture area was effective in patent foramen ovale closure and exhibited positive sealing performance and biological compatibility. Trans-septal puncture was feasible and effective after reserved atrial septal puncture area patent foramen ovale closure.
卵圆孔未闭介入封堵后，通过封堵器穿刺房间隔进行进一步介入治疗较为困难，但有时需要进行。本文介绍了一种预留房间隔穿刺面积卵圆孔未闭封堵器的体内实验研究结果。
通过卵圆窝经皮穿刺和高压球囊扩张，在犬中建立卵圆孔未闭模型。然后，使用预留房间隔穿刺面积进行卵圆孔未闭封堵，所有犬均饲养 3 个月。然后，穿过封堵器进行左心房造影，并在封堵器所在的房间隔区域进行左心房造影。最后，使用 DSA 血管造影、超声心动图和组织学评估预留房间隔穿刺面积的性能和可行性。
通过心房穿刺法成功建立了 10 只犬的卵圆孔未闭模型。卵圆孔未闭的平均直径为 3.77±0.19mm，使用预留房间隔穿刺面积成功地关闭了所有犬的卵圆孔未闭。经食管超声心动图评估，新型封堵器位置理想，术中及术后完全封堵，无残余分流。新的封堵器实现了 100%的心房穿刺成功率。植入后 3 个月，封堵器完全内皮化。
预留房间隔穿刺面积对卵圆孔未闭闭合有效，具有良好的密封性能和生物相容性。经皮穿刺在预留房间隔穿刺面积卵圆孔未闭闭合后是可行和有效的。
