ISF College of Pharmacy, Moga, 142001, Punjab, India.
Recent Adv Antiinfect Drug Discov. 2022;17(3):187-198. doi: 10.2174/2772434417666220905121531.
Recently, natural products have been became the center of attraction for the scientific society and exploration of their biologically abilities is proceeding continuously. In search for novel antiparasitic agents with an objective of protecting humans from parasitic infections, the present work was focused on naphthoquinones possessing antiparasitic activity. Among naphthoquinones, plumbagin is one of the secondary metabolites exhibiting diverse biological properties such as antibacterial, antimalarial, antiinflammatory, insecticidal and antiparasitic. Plumbagin is reported to have antischistosomiasis, anti-haemonchosis, anti-fascioliasis, antiotoacariasis, anti-leishmaniasis, antimalaria, antiallergic and anthelmintic activities. Besides, various methods of extraction of plumbagin from different methods, their effectiveness against different parasites, and the structure-activity relationship reported by different researchers. This work highlight on recent advancements in the phytochemistry of plumbagin, studies associated with various biological activities. The structure-activity relationship studies have also been summarized. To conclude, present review could be beneficial for the scientific community to get better insight into medicinal research of plumbagin and may provide a new horizon for the rational design of plumbagin based compounds.
最近，天然产物已成为科学界关注的焦点，对其生物活性的探索一直在持续进行。为了寻找具有新颖抗寄生虫活性的新型抗寄生虫药物，本工作集中研究了具有抗寄生虫活性的萘醌类化合物。在萘醌类化合物中，铅丹是一种具有多种生物活性的次级代谢产物，如抗菌、抗疟、抗炎、杀虫和抗寄生虫。铅丹已被报道具有抗血吸虫病、抗肝片吸虫病、抗肝片形吸虫病、抗耳螨病、抗利什曼病、抗疟疾、抗过敏和驱虫活性。此外，还介绍了从不同方法中提取铅丹的各种方法、它们对不同寄生虫的有效性，以及不同研究人员报道的结构-活性关系。本工作重点介绍了铅丹的植物化学最近的进展，以及与各种生物活性相关的研究。也总结了结构-活性关系的研究。总之，本综述可为科学界提供更好地了解铅丹药用研究的机会，并可能为基于铅丹的化合物的合理设计提供新的视野。
