Petrocelli Giovannamaria, Marrazzo Pasquale, Bonsi Laura, Facchin Federica, Alviano Francesco, Canaider Silvia
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, BO, Italy.
Department of Biomedical and Neuromotor Science, University of Bologna, 40126 Bologna, BO, Italy.
Life (Basel). 2023 May 31;13(6):1303. doi: 10.3390/life13061303.
Phytochemicals from various medicinal plants are well known for their antioxidant properties and anti-cancer effects. Many of these bioactive compounds or natural products have demonstrated effects against inflammation, while some showed a role that is only approximately described as anti-inflammatory. In particular, naphthoquinones are naturally-occurring compounds with different pharmacological activities and allow easy scaffold modification for drug design approaches. Among this class of compounds, Plumbagin, a plant-derived product, has shown interesting counteracting effects in many inflammation models. However, scientific knowledge about the beneficial effect of Plumbagin should be comprehensively reported before candidating this natural molecule into a future drug against specific human diseases. In this review, the most relevant mechanisms in which Plumbagin plays a role in the process of inflammation were summarized. Other relevant bioactive effects were reviewed to provide a complete and compact scenario of Plumbagin's potential therapeutic significance.
各种药用植物中的植物化学物质以其抗氧化特性和抗癌作用而闻名。这些生物活性化合物或天然产物中的许多已显示出抗炎作用，而有些仅表现出大致可描述为抗炎的作用。特别是，萘醌是具有不同药理活性的天然存在的化合物，便于对药物设计方法进行支架修饰。在这类化合物中，一种植物源产物白花丹醌在许多炎症模型中都显示出有趣的对抗作用。然而，在将这种天然分子作为未来治疗特定人类疾病的药物进行候选之前，应全面报道有关白花丹醌有益作用的科学知识。在这篇综述中，总结了白花丹醌在炎症过程中发挥作用的最相关机制。还综述了其他相关的生物活性作用，以提供白花丹醌潜在治疗意义的完整而简洁的情况。
