Roy Arpita, Bharadvaja Navneeta
Plant Biotechnology Laboratory, Department of Biotechnology, Delhi Technological University, New Delhi-110042, India.
Curr Pharm Biotechnol. 2018;19(5):372-381. doi: 10.2174/1389201019666180629143842.
Increased demand for compounds that are derived from natural source are gaining more and more importance. Plumbagin is a plant naphthoquinone which is present in several families, including Iridaceae, Plumbaginaceae, Ebenceae, Drosophyllaceae, Nepenthaceae and Droseraceae. Plumbagin possesses high therapeutic efficacy and minimal side effects. It has various pharmaceutical activities which include anticancer, antibacterial, anti-inflammatory, antioxidant, antifungal, neuroprotective and hypolipidemic activities. In natural habitat, production of plumbagin is low due to species variations and environmental changes, considering importance of this bioactive compound, alternative techniques for its enhanced production needs to be devised. In the present review, various production techniques and scale-up strategies for plumbagin production are discussed.
Aim of this review is to provide an insight into the chemistry of plumbagin, its pharmaceutical activities, perspective of cell suspension culture, root culture, hairy root culture and scale up strategies for its production.
All the data compiled and presented here were obtained from various E-resources like Pubmed, Science Direct, and Google Scholar up to February 2018.
This review comprises isolation, extraction and quantification method for plumbagin, its pharmaceutical activities, various tissue culture production techniques and scale-up strategies for enhanced production.
Plumbagin is an important phytocompound which shows potential towards treatments of various diseases. Demand for the production of plumbagin continuously increasing worldwide due to its pharmacological properties. To fulfil commercial demand of plumbagin alternative technologies need to be investigated. Biotechnological approaches like cell suspension culture, root suspension culture and hairy root culture are alternative techniques for plumbagin production. These techniques provide continuous supply of bioactive compounds. However, research on various aspects of tissue culture production techniques is in preparatory stage and requires culture and process optimization for development of a commercially practical process.
对天然来源化合物的需求不断增加，其重要性日益凸显。白花丹醌是一种植物萘醌，存在于多个科中，包括鸢尾科、白花丹科、柿树科、露叶茅膏菜科、猪笼草科和茅膏菜科。白花丹醌具有高治疗效果和最小的副作用。它具有多种药理活性，包括抗癌、抗菌、抗炎、抗氧化、抗真菌、神经保护和降血脂活性。在自然环境中，由于物种变异和环境变化，白花丹醌的产量较低，考虑到这种生物活性化合物的重要性，需要设计替代技术来提高其产量。在本综述中，讨论了白花丹醌生产的各种技术和放大策略。
本综述的目的是深入了解白花丹醌的化学性质、其药理活性、细胞悬浮培养、根培养、毛状根培养的前景及其生产的放大策略。
此处汇编和呈现的所有数据均截至2018年2月从各种电子资源中获取，如PubMed、科学Direct和谷歌学术。
本综述包括白花丹醌的分离、提取和定量方法、其药理活性、各种组织培养生产技术以及提高产量的放大策略。
白花丹醌是一种重要的植物化合物，对多种疾病的治疗显示出潜力。由于其药理特性，全球对白花丹醌生产的需求持续增加。为满足白花丹醌的商业需求，需要研究替代技术。细胞悬浮培养、根悬浮培养和毛状根培养等生物技术方法是生产白花丹醌的替代技术。这些技术提供了生物活性化合物的持续供应。然而，组织培养生产技术各方面的研究尚处于准备阶段，需要进行培养和工艺优化以开发出商业上可行的工艺。
