Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic disease, University of South China, Hengyang, China.
Eur Rev Med Pharmacol Sci. 2022 Aug;26(16):5689-5697. doi: 10.26355/eurrev_202208_29503.
This study aims to summarize the role of PIWIs/piRNAs in cell apoptosis through multiple signaling pathways. The PIWI-interacting RNAs (piRNAs) are among the small non-coding RNAs (sncRNAs) and are mainly expressed in germline cells. PIWI protein is the key to the biogenesis of piRNA. With the deepening of research in recent years, the PIWIs/piRNAs are expressed in a tissue-specific way in somatic cells outside the germline. In addition, researchers have found that the PIWIs/piRNAs play a regulatory role in cell apoptosis, proliferation, and necrosis by regulating key signaling pathways, such as PI3K/Akt signaling pathway, STAT signaling pathway, TGF-β signaling pathway, and Fas signaling pathway at the transcriptional or post-transcriptional level. However, the PIWIs/piRNAs' role in cell apoptosis and its underlying mechanisms are still not fully understood. This study reviews the regulatory functions of PIWIs/piRNAs in apoptosis from the perspective of the signal pathway.
This study is a narrative review. PubMed and MEDLINE were used as the primary sources to search the following keywords: PIWI/piRNAs, signal pathway, pro-apoptotic, anti-apoptotic, and signaling pathway.
PIWIs/piRNAs modulated pro-apoptotic or anti-apoptotic effects in a variety of cells: PIWIs/piRNAs through PI3K/Akt signaling pathway, STAT signaling pathway, TGF-β signaling pathway, and Fas signaling pathway for pro-apoptotic or anti-apoptotic effects in cells.
Apoptosis is a basic biological phenomenon of cell death, and it also has a great significance and complex molecular biological mechanisms. PIWI/piRNAs are closely related to various types of diseases and play a pro-apoptotic or anti-apoptotic role through the following pathways: PI3K/Akt signaling, STAT signaling, TGF-β signaling, and Fas signaling pathways.
本研究旨在通过多种信号通路总结 PIWIs/piRNAs 在细胞凋亡中的作用。PIWI 相互作用 RNA（piRNAs）是小非编码 RNA（sncRNAs）之一，主要在生殖细胞中表达。PIWI 蛋白是 piRNA 生物发生的关键。近年来随着研究的深入，PIWIs/piRNAs 在生殖细胞外的体细胞中以组织特异性的方式表达。此外，研究人员发现，PIWIs/piRNAs 通过调节 PI3K/Akt 信号通路、STAT 信号通路、TGF-β 信号通路和 Fas 信号通路等关键信号通路，在转录或转录后水平上调节细胞凋亡、增殖和坏死的关键信号通路，发挥调控作用。然而，PIWIs/piRNAs 在细胞凋亡中的作用及其潜在机制尚不完全清楚。本研究从信号通路的角度综述了 PIWIs/piRNAs 对细胞凋亡的调控作用。
本研究为叙述性综述。以 PubMed 和 MEDLINE 为主要数据源，检索以下关键词：PIWI/piRNAs、信号通路、促凋亡、抗凋亡和信号通路。
PIWIs/piRNAs 在多种细胞中调节促凋亡或抗凋亡作用：PIWIs/piRNAs 通过 PI3K/Akt 信号通路、STAT 信号通路、TGF-β 信号通路和 Fas 信号通路在细胞中发挥促凋亡或抗凋亡作用。
细胞凋亡是细胞死亡的一种基本生物学现象，它也具有重要的意义和复杂的分子生物学机制。PIWI/piRNAs 与多种疾病密切相关，通过 PI3K/Akt 信号通路、STAT 信号通路、TGF-β 信号通路和 Fas 信号通路发挥促凋亡或抗凋亡作用。
