先天免疫：适应性 NK 细胞的演进范例。
Innatus immunis: Evolving paradigm of adaptive NK cells.
机构信息
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI.
Blood Research Institute, Versiti, Milwaukee, WI.
出版信息
J Exp Med. 2022 Nov 7;219(11). doi: 10.1084/jem.20221254. Epub 2022 Sep 6.
The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220551) report that the development of FcRγ-/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α. These findings provide exciting new molecular blueprints explaining the development and functions of adaptive-like NK cells.
调控适应性样 NK 细胞发育的机制尚不清楚。Shemesh 等人（2022. J. Exp. Med.https://doi.org/10.1084/jem.20220551）报道称，FcRγ-/low 适应性样 NK 细胞的发育需要降低 mTOR 活性，并依赖于 TGF-β 或 IFN-α。这些发现为解释适应性样 NK 细胞的发育和功能提供了令人兴奋的新分子蓝图。
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