烷基磷酰胆碱及其相关衍生物对杜氏利什曼原虫的活性。
The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.
作者信息
Croft S L, Neal R A, Pendergast W, Chan J H
出版信息
Biochem Pharmacol. 1987 Aug 15;36(16):2633-6. doi: 10.1016/0006-2952(87)90543-0.
PMID:3606662
Abstract
Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.
摘要
在体外对小鼠腹膜巨噬细胞内的杜氏利什曼原虫无鞭毛体测试了几种烷基磷酰胆碱及其相关衍生物，并测定出其半数有效浓度（ED50）值在1至12微摩尔范围内。在BALB/c小鼠中对杜氏利什曼原虫测试的三种烷基磷酰胆碱具有活性，其中一种化合物的半数有效剂量为12.8毫克/千克/天×5，但一种烷基磷酰乙醇胺无活性。
Zotero 插件