Division of Environmental Medicine and Population Sciences, Department of Social Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Division of Epidemiology, National Cancer Center Institute for Cancer Control, Chuo-ku, Tokyo, Japan.
Cancer Epidemiol Biomarkers Prev. 2022 Nov 2;31(11):2011-2019. doi: 10.1158/1055-9965.EPI-22-0216.
Several studies have investigated the association between alcohol consumption and pancreatic cancer risk. However, these studies reported inconsistent results.
This study included 95,812 participants from the Japan Public Health Center-Based Prospective Study, whose alcohol drinking habit was collected through the questionnaire of the baseline survey in 1990 to 1994 for Cohort I and in 1993 to 1995 for Cohort II, and followed-up until December 2013. The hazard ratios (HR) and 95% confidence intervals (CI) were calculated using multivariable-adjusted Cox proportional hazard regression models.
During 1,969,101 person-years of follow-up, 598 patients (315 men and 283 women) were newly diagnosed with pancreatic cancer. No association was observed between alcohol consumption at baseline and pancreatic cancer risk in either men or women, even in the analyses conducted among men stratified by facial flushing responses or smoking status. When the population was limited to men whose alcohol drinking habit remained unchanged from the baseline survey to the 5-year follow-up survey, a significant association was observed in drinkers with alcohol consumption of 1 to 299 g/week compared with non/occasional drinkers (multivariable-adjusted HR, 1.73; 95% CI, 1.15-2.60).
A significant association between alcohol consumption and pancreatic cancer risk was observed when the population was limited to men with a 5-year unchanged alcohol drinking habit and was particularly strong in never smokers.
This study suggested an association between continuous alcohol consumption and pancreatic cancer risk in the Japanese population. However, further investigations using other cohort studies are required.
多项研究调查了饮酒与胰腺癌风险之间的关联。然而，这些研究结果并不一致。
本研究纳入了 95812 名来自日本公共卫生中心前瞻性研究的参与者，其饮酒习惯通过 1990 年至 1994 年的基线调查问卷（队列 I）和 1993 年至 1995 年的问卷（队列 II）收集，随访至 2013 年 12 月。使用多变量调整的 Cox 比例风险回归模型计算危险比（HR）和 95%置信区间（CI）。
在 1969101 人年的随访期间，598 名患者（315 名男性和 283 名女性）被新诊断为胰腺癌。在男性或女性中，基线饮酒与胰腺癌风险之间均未观察到关联，即使在根据面部潮红反应或吸烟状况对男性进行分层的分析中也是如此。当将人群限于酒精饮酒习惯从基线调查到 5 年随访调查保持不变的男性时，与非/偶尔饮酒者相比，每周饮酒 1 至 299 克的饮酒者中观察到显著关联（多变量调整的 HR，1.73；95%CI，1.15-2.60）。
当将人群限于酒精饮酒习惯 5 年不变且为非吸烟者的男性时，观察到饮酒与胰腺癌风险之间存在显著关联。
本研究提示在日本人群中，持续饮酒与胰腺癌风险之间存在关联。然而，需要使用其他队列研究进行进一步的调查。
