具有生物活性的新型咪唑-5-碳异羟肟酸
New imidazole-5-carbohydroxamic acids with biological activity.
作者信息
Bossio R, Capei R, Marcaccini S, Pepino R, Tiscione E
出版信息
Arzneimittelforschung. 1987 Apr;37(4):377-9. doi: 10.1002/chin.198734193.
PMID:3606692
Abstract
A series of 1-benzyl-2-arylthio (or heteroarylthio)-5-imidazolecarbohydroxamic acids (Va-e) was prepared starting from the corresponding imidazole-5-carboxylic acids IIIa-e via acid chlorides IVa-e. Tests of biological activity showed that compounds Va-e are fairly active against Escherichia coli and Candida albicans.
摘要
从相应的咪唑-5-羧酸IIIa-e出发，经酰氯IVa-e制备了一系列1-苄基-2-芳硫基（或杂芳硫基）-5-咪唑碳羟肟酸（Va-e）。生物活性测试表明，化合物Va-e对大肠杆菌和白色念珠菌具有相当的活性。
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