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N,N-二烷基-2-取代-5-重氮咪唑-4-甲酰胺的合成及其抗菌活性

Synthesis and antimicrobial activity of N, N-dialkyl-2-substituted-5-diazo-imidazole-4-carboxamides.

作者信息

Varoli L, Burnelli S, Garuti L, Guarnieri A, Rossi M

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.

出版信息

Pharmazie. 1997 Aug;52(8):578-81.

PMID:9292914
Abstract

A series of 2-substituted-5-diazoimidazole-4-carboxamides has been synthesized, and their antimicrobial activity has been tested in vitro. Some of the compounds show antifungal activity related to the presence of small groups on the 4-carbox-amido moiety, while the presence of substituents in position 2 was detrimental.

摘要

已经合成了一系列2-取代-5-重氮咪唑-4-甲酰胺，并对它们的抗菌活性进行了体外测试。一些化合物表现出与4-羧酰胺部分上存在小基团相关的抗真菌活性，而2位上存在取代基则是有害的。

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