Cortat M, Fels P
Arzneimittelforschung. 1987 Apr;37(4):463-6.
Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of N-benzyl, N-dodecyl-N,N-di(2-hydroxyethyl)ammonium chloride (benzoxonium chloride, Orofar), a quaternary ammonium salt, were assayed on 14 strains associated with buccopharyngeal infections. MICs ranged between 2-5 micrograms/ml for Gram-positive bacteria and between 16 and 48 micrograms/ml for Gram-negative organisms. For Candida albicans they were between 6-8 micrograms/ml. MBCs for 1 and 2 min were only slightly higher than MICs. One strain of K. pneumoniae required, however, 100 micrograms/ml and 10 min of exposure. Results show that benzoxonium chloride has strong antimicrobial effect on organisms responsible for buccopharyngeal infections.
对14株与口咽感染相关的菌株测定了季铵盐N-苄基-N-十二烷基-N，N-二（2-羟乙基）氯化铵（苯氧铵，Orofar）的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。革兰氏阳性菌的MIC范围为2至5微克/毫升，革兰氏阴性菌为16至48微克/毫升。白色念珠菌的MIC在6至8微克/毫升之间。1分钟和2分钟的MBC仅略高于MIC。然而，一株肺炎克雷伯菌需要100微克/毫升和10分钟的暴露时间。结果表明，苯氧铵对引起口咽感染的生物体具有很强的抗菌作用。
