Weibel M A, Cortat M, Lebek G, LeCotonnec J Y, Kitler M E, Barcherini G
Arzneimittelforschung. 1987 Apr;37(4):467-71.
Different pharmaceutical forms of N-benzyl,N-dodecyl-N,N-di(2-hydroxyethyl) ammonium chloride (benzoxonium chloride, Orofar) have been tested on the overall buccopharyngeal bacterial count in healthy volunteers, and compared to competitors. Gargle solutions are most effective in reducing initial bacterial count. An open repeated dose study has been performed on 38 patients with sore throat to assess the safety and the efficacy of benzoxonium chloride tablets and gelsolets at doses of 6 mg and 10 mg daily for 4 to 6 days. Pathogens disappeared or were clearly reduced and the syndrome resolved. Tolerance was good. Differences in methodologies are discussed.
已对不同剂型的N-苄基-N-十二烷基-N,N-二（2-羟乙基）氯化铵（苯氧铵，奥罗法）在健康志愿者的口腔咽喉细菌总数上进行了测试，并与竞品进行了比较。含漱液在降低初始细菌数量方面最为有效。对38名咽喉痛患者进行了一项开放性重复剂量研究，以评估苯氧铵片剂和凝胶含片每日6毫克和10毫克剂量、持续4至6天的安全性和有效性。病原体消失或明显减少，症状得到缓解。耐受性良好。文中讨论了方法上的差异。
