门腔静脉吻合术对瘦型和肥胖型 Zucker 大鼠血浆脂蛋白的影响。
Effect of portacaval anastomosis on plasma lipoproteins of lean and obese Zucker rats.
作者信息
Mathé D, Bendjellit S, Castaing D
出版信息
Atherosclerosis. 1987 Apr;64(2-3):155-62. doi: 10.1016/0021-9150(87)90241-3.
The distribution of cholesterol (C), triglycerides (TG), phospholipids (PL) and proteins in the different lipoproteins was studied in lean and obese Zucker rats under 2 conditions: non-operated and after portacaval anastomosis (PCA). All lipoproteins, but mainly the d less than 1.006 g/ml (chylomicrons + VLDL) fraction, were increased in obese rats. They were hypertriglyceridemic (+ 675%) and hypercholesterolemic (+ 207%). PCA decreased cholesterolemia by about 50% and triglyceridemia by 50-70% in both lean and obese rats. Except for VLDL, enriched in TG in obese rats, proportions of C, TG, PL and proteins in lipoproteins were about the same in obese and lean Zucker rats and were nearly unchanged by PCA, suggesting an increased number of particles in obese rats and a decreased number after PCA. Lipoproteins of obese rats were enriched in apo C and proportions of apo E and apo B were decreased in the d less than 1.006 g/ml fraction. PCA decreased the proportion of apo C in all lipoproteins.
在两种情况下，即未手术和门腔静脉吻合术（PCA）后，对瘦型和肥胖型 Zucker 大鼠不同脂蛋白中胆固醇（C）、甘油三酯（TG）、磷脂（PL）和蛋白质的分布进行了研究。在肥胖大鼠中，所有脂蛋白均增加，但主要是密度小于 1.006 g/ml（乳糜微粒 + 极低密度脂蛋白）的部分。它们表现为高甘油三酯血症（+675%）和高胆固醇血症（+207%）。在瘦型和肥胖型大鼠中，PCA 均使胆固醇血症降低约 50%，甘油三酯血症降低 50 - 70%。除了在肥胖大鼠中富含 TG 的极低密度脂蛋白外，肥胖型和瘦型 Zucker 大鼠脂蛋白中 C、TG、PL 和蛋白质的比例大致相同，且 PCA 后几乎没有变化，这表明肥胖大鼠中颗粒数量增加，而 PCA 后颗粒数量减少。肥胖大鼠的脂蛋白富含载脂蛋白 C，在密度小于 1.006 g/ml 的部分中，载脂蛋白 E 和载脂蛋白 B 的比例降低。PCA 降低了所有脂蛋白中载脂蛋白 C 的比例。
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