Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Physiology (Bethesda). 2023 Jan 1;38(1):0. doi: 10.1152/physiol.00018.2022. Epub 2022 Sep 6.
After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle resting state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulating the ATP demand in health and disease. Finally, we present current experimental drugs targeting myosin ATP consumption and how they can treat muscle diseases.
经过多年使用结构、生物和生化实验程序的深入研究，肌球蛋白分子对于横纹肌收缩是必不可少的，这一点已经很清楚了。然而，这仅仅是它们功能的冰山一角。有趣的是，最近已经表明，这些分子（尤其是肌球蛋白重链）对于心脏和骨骼肌肉的静息状态也至关重要。在本综述中，我们首先概述肌球蛋白重链的生化状态以及它们如何影响 ATP 的消耗。然后详细介绍包括肌球蛋白轻链和肌球蛋白结合蛋白 C 在内的相邻伴侣蛋白如何干预这些过程，调节健康和疾病中的 ATP 需求。最后，我们介绍了目前针对肌球蛋白 ATP 消耗的实验性药物以及它们如何治疗肌肉疾病。
