Hariharan S, Tseng H, Myers S A
Am J Perinatol. 1987 Jul;4(3):235-9. doi: 10.1055/s-2007-999781.
Hemodynamic studies were performed in 11 conscious pregnant guinea pigs using radioactive microspheres to calculate the effects of angiotensin II (AII) infusion. A dose-dependent increase of the mean arterial pressure and systemic vascular resistance during AII infusion was observed. A significant increase in in uteroplacental flow also occurred without a change in cardiac output or uteroplacental vascular resistance. These data demonstrate that the systemic and uterine vasculatures of the pregnant guinea pig have different responses to AII infusion.
使用放射性微球对11只清醒的妊娠豚鼠进行血流动力学研究，以计算血管紧张素II（AII）输注的影响。观察到在AII输注期间平均动脉压和全身血管阻力呈剂量依赖性增加。子宫胎盘血流量也显著增加，而心输出量或子宫胎盘血管阻力没有变化。这些数据表明，妊娠豚鼠的全身和子宫血管系统对AII输注有不同反应。
