Institute for Health Innovation and Technology, National University of Singapore, Singapore, 117599, Singapore; Department of Electrical and Computer Engineering, National University of Singapore, Singapore, 117583, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore, 117456, Singapore.
Institute for Health Innovation and Technology, National University of Singapore, Singapore, 117599, Singapore.
Biosens Bioelectron. 2022 Nov 15;216:114651. doi: 10.1016/j.bios.2022.114651. Epub 2022 Aug 31.
Extravasation is a common complication during intravenous therapy in which infused fluids leak into the surrounding tissues. Timely intervention can prevent severe adverse consequences, but early detection remains an unmet clinical need because existing sensors are not sensitive to leakage occurring in small volumes (< 200 μL) or at deep venipuncture sites. Here, an ultrathin bioimpedance microsensor array that can be integrated on intravenous needles for early and sensitive detection of extravasation is reported. The array comprises eight microelectrodes fabricated on an ultrathin and flexible polyimide substrate as well as functionalized using poly(3,4-ethylenedioxythiophene) and multi-walled carbon nanotubes. Needle integration places the array proximity to venipuncture site, and functional coating significantly reduces interface impedance, both enable the microsensors with high sensitivity to detect early extravasation. In vitro and in vivo experiments demonstrate the capability of the microsensors to differentiate various intravenous solutions from different tissue layers as well as identify saline extravasation with detection limit as low as 20 μL.
外渗是静脉治疗中常见的并发症，其中输注的液体漏入周围组织。及时干预可以防止严重的不良后果，但早期检测仍然是未满足的临床需求，因为现有的传感器对小体积（<200μL）或深部静脉穿刺部位发生的渗漏不敏感。在这里，报道了一种超轻薄的生物阻抗微传感器阵列，可集成在静脉针上，用于早期和灵敏地检测外渗。该阵列由八个微电极组成，这些微电极在超薄且灵活的聚酰亚胺基底上制造，并通过聚（3,4-亚乙基二氧噻吩）和多壁碳纳米管进行功能化。针的集成将阵列置于接近静脉穿刺部位，功能涂层显著降低了界面阻抗，这两者都使微传感器具有高灵敏度，能够早期检测外渗。体外和体内实验证明了微传感器能够区分不同静脉溶液和不同组织层的能力，并且能够以低至 20μL 的检测限识别盐水外渗。
