KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; email:
Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Annu Rev Pathol. 2023 Jan 24;18:47-70. doi: 10.1146/annurev-pathmechdis-031521-032634. Epub 2022 Sep 6.
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understood. The condition is characterized by hypersensitivity to cereal gluten proteins, and the disease lesion is localized in the gut. Still, the diagnosis can be made by detection of highly disease-specific autoantibodies to transglutaminase 2 in the blood. We now have mechanistic insights into how the disease-predisposing HLA-DQ molecules, via presentation of posttranslationally modified gluten peptides, are connected to the generation of these autoantibodies. This review presents our current understanding of the immunobiology of this common disorder that is positioned in the border zone between food hypersensitivity and autoimmunity.
在人类白细胞抗原 (HLA) 相关疾病中，乳糜泻的免疫发病机制尤其清楚。这种疾病的特征是对谷物麸质蛋白过敏，病变部位在肠道。然而，通过检测血液中转谷氨酰胺酶 2 的高度疾病特异性自身抗体可以做出诊断。我们现在对疾病易感性 HLA-DQ 分子如何通过呈现翻译后修饰的谷氨酰胺肽与这些自身抗体的产生之间的联系有了机制上的了解。这篇综述介绍了我们目前对这种常见疾病的免疫生物学的理解，这种疾病位于食物过敏和自身免疫之间的边缘地带。
