Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) - Guwahati, Changsari, Kamrup, Assam 781101, India.
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Environ Toxicol Pharmacol. 2022 Oct;95:103970. doi: 10.1016/j.etap.2022.103970. Epub 2022 Sep 5.
Rapid industrial and technological development has impacted ecosystem homeostasis strongly. Arsenic is one of the most detrimental environmental toxins and its management with chelating agents remains a matter of concern due to associated adverse effects. Thus, safer and more effective alternative therapy is required to manage arsenic toxicity. Based on existing evidence, native and indigenous plant-based active biomolecules appear as a promising strategy to mitigate arsenic-induced toxicity with an acceptable safety profile. In this regard, various phytochemicals (flavonoids and stilbenoids) are considered important classes of polyphenolic compounds with antioxidant and chelation effects, which may facilitate the removal of arsenic from the body more effectively and safely with regard to conventional approaches. This review presents an overview of conventional chelating agents and the potential role of flavonoids and stilbenoids in ameliorating arsenic toxicity. This report may provide a roadmap for identifying novel prophylactic/therapeutic strategies for managing arsenic toxicity.
快速的工业和技术发展对生态系统的动态平衡产生了强烈的影响。砷是最具危害性的环境毒素之一，由于其相关的副作用，用螯合剂来管理它仍然是一个令人关注的问题。因此，需要更安全、更有效的替代疗法来管理砷毒性。基于现有证据，天然和本土植物来源的活性生物分子似乎是一种有前途的策略，可以减轻砷诱导的毒性，同时具有可接受的安全性。在这方面，各种植物化学物质（类黄酮和芪类）被认为是具有抗氧化和螯合作用的重要多酚类化合物，与传统方法相比，它们可能更有效地、更安全地促进砷从体内排出。本综述概述了传统的螯合剂以及类黄酮和芪类在减轻砷毒性方面的潜在作用。本报告可能为确定管理砷毒性的新的预防/治疗策略提供了一个路线图。
