Bi Xiaojie, Zhang Ying, Pan Juan, Chen Chaochao, Zheng Yufen, Wang Jing, Chen Mengyuan, Zhou Kai, Tung Tao-Hsin, Shen Bo, Wang Donglian
Department of Laboratory Medicine, Taizhou Hospital, Zhejiang University, Linhai, 317000, People's Republic of China.
Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People's Republic of China.
Infect Drug Resist. 2022 Aug 31;15:5111-5120. doi: 10.2147/IDR.S378990. eCollection 2022.
We evaluated the differences between patients with SARS-CoV-2 Omicron variant infections and Fever outpatients, so that prevention and control measures can be taken in time.
This study retrospectively analyzed 65 patients with SARS-CoV-2 Omicron variant. Sixty-nine age- and sex-matched Fever outpatients were enrolled during the same period of time. We also reanalyzed data from 81 SARS-CoV-2 Wild-Type-infected patients. We compared the clinical characteristics and initial indexes of routine tests among the 3 groups.
A total of 93.8% of the patients with Omicron infections had clinical symptoms, and the major symptoms were cough, fever and pharyngalgia. Pharyngalgia was a specific manifestation in Omicron group compared to Wild-Type group. The white blood cell of the Omicron group was lower than that of the Fever group [5.0 (3.6-6.1) vs 10.1 (7.6-12.9) ×10/L, P < 0.001]. The neutrophil count in Omicron group was lower than that in Fever and Wild-Type group [2.6 (1.8-3.9) vs 8.1 (5.9-10.9), P < 0.001; 2.6 (1.8-3.9) vs 3.4 (2.5-4.7) ×10/L, P < 0.001]. The white blood cell and neutrophil counts were lower in Omicron group than in the Fever group. The top 5 major symptoms were fever, cough, pharyngalgia, headache and expectoration.
There are differences between the patients with Omicron infections and Fever outpatients, both in clinical manifestations and initial routine hematology indicators. We hope to provide some clues for early identification combined with a history of living in the epidemic area.
我们评估了感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）奥密克戎变异株的患者与发热门诊患者之间的差异，以便及时采取防控措施。
本研究回顾性分析了65例感染SARS-CoV-2奥密克戎变异株的患者。同期纳入69例年龄和性别匹配的发热门诊患者。我们还重新分析了81例感染SARS-CoV-2野生型患者的数据。我们比较了三组患者的临床特征和血常规初始指标。
奥密克戎感染患者中共有93.8%出现临床症状，主要症状为咳嗽、发热和咽痛。与野生型组相比，咽痛是奥密克戎组的特异性表现。奥密克戎组的白细胞低于发热组[5.0（3.6 - 6.1）对10.1（7.6 - 12.9）×10⁹/L，P < 0.001]。奥密克戎组的中性粒细胞计数低于发热组和野生型组[2.6（1.8 - 3.9）对8.1（5.9 - 10.9），P < 0.001；2.6（1.8 - 3.9）对3.4（2.5 - 4.7）×10⁹/L，P < 0.001]。奥密克戎组的白细胞和中性粒细胞计数低于发热组。前5大主要症状为发热、咳嗽、咽痛、头痛和咳痰。
奥密克戎感染患者与发热门诊患者在临床表现和血常规初始指标方面均存在差异。我们希望结合疫区居住史为早期识别提供一些线索。
