姜黄素衍生物在乳腺癌治疗中的最新进展
Recent Advances of Curcumin Derivatives in Breast Cancer.
作者信息
Yin Ying, Tan Yan, Wei Xueni, Li Xiaoshun, Chen Hongfei, Yang Zehua, Tang Guotao, Yao Xu, Mi Pengbing, Zheng Xing
机构信息
Group of Lead Compound, Department of Pharmacy, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, 421001, China.
出版信息
Chem Biodivers. 2022 Oct;19(10):e202200485. doi: 10.1002/cbdv.202200485. Epub 2022 Sep 26.
Curcumin is a potential plant-derived drug for the treatment of breast cancer. Poor solubility and bioavailability are the main factors that limit its clinical application. Various structural modification strategies have been developed to improve the anti-breast cancer activity of curcumin. This review focuses on the difference of modification sites and heterocyclic/non-heterocyclic modifications to systematically summarize curcumin derivatives with better anti-breast cancer activity.
姜黄素是一种有潜力的植物源药物，用于治疗乳腺癌。溶解度差和生物利用度低是限制其临床应用的主要因素。人们已经开发了各种结构修饰策略来提高姜黄素的抗乳腺癌活性。本文综述聚焦于修饰位点的差异以及杂环/非杂环修饰，以系统总结具有更好抗乳腺癌活性的姜黄素衍生物。
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