非手术治疗对牙周炎患者血浆C反应蛋白水平的影响：单臂前瞻性临床试验。
Effect of non-surgical therapy on plasma C-reactive protein levels in patients with periodontitis: A single arm prospective clinical trial.
作者信息
Shah Bansari, Shah Monali, Geisinger Maria, Saleh Muhammad H A, Meghil Mohamed, Wang Hom-Lay
机构信息
Department of Periodontics, University of Louisville School of Dentistry, Louisville, Kentucky, USA.
Department of Periodontology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
出版信息
J Periodontol. 2023 Mar;94(3):336-343. doi: 10.1002/JPER.22-0231. Epub 2022 Nov 29.
BACKGROUND
This study aimed to evaluate the effect of scaling and root planing (SRP) on levels of plasma C-reactive protein (CRP).
METHODS
A total of 30 patients with advanced periodontitis as determined by Clinical Periodontal Sum Score (CPSS) were recruited. Venous whole blood samples were drawn to obtain serum samples from all participants at baseline and 1 month after SRP (post-SRP). High-sensitivity CRP (hs-CRP) was measured by highly sensitive immunoturbidimetric assay. Wilcoxon signed-rank test was used for data analysis. Spearman rank correlation analysis was conducted to test the correlations between CPSS and hs-CRP at baseline and post-SRP.
RESULTS
There was a statistically significant reduction in the post-SRP CPSS values from the baseline values (z = 4.783, p < 0.0001). Similarly, there was a statistically significant reduction in the post-SRP hs-CRP levels from the baseline levels (z = 4.782, p < 0.0001). Moreover, there was positive association between the baseline levels of CPSS and hs-CRP (ρ = 0.5703) and the post-SRP values of CPSS and hs-CRP (ρ = 0.7507).
CONCLUSION
The present study suggests that SRP can significantly reduce the levels of CRP.
背景
本研究旨在评估龈下刮治术和根面平整术（SRP）对血浆C反应蛋白（CRP）水平的影响。
方法
招募了30例经临床牙周综合评分（CPSS）确定为重度牙周炎的患者。在基线时以及SRP术后1个月（SRP后）采集所有参与者的静脉全血样本以获取血清样本。采用高敏免疫比浊法测定高敏CRP（hs-CRP）。数据分析采用Wilcoxon符号秩检验。进行Spearman等级相关分析以检验基线时和SRP后CPSS与hs-CRP之间的相关性。
结果
SRP后CPSS值较基线值有统计学意义的降低（z = 4.783，p < 0.0001）。同样，SRP后hs-CRP水平较基线水平有统计学意义的降低（z = 4.782，p < 0.0001）。此外，基线时CPSS与hs-CRP水平之间（ρ = 0.5703）以及SRP后CPSS与hs-CRP值之间（ρ = 0.7507）存在正相关。
结论
本研究表明SRP可显著降低CRP水平。
Zotero 插件