Department of Applied Chemistry, Maulana Abul Kalam Azad University of Technology, West Bengal, Simhat, Haringhata, 741249, Nadia, India.
Department of Chemistry, Jadavpur University, Kolkata-700032, India.
Org Biomol Chem. 2022 Sep 21;20(36):7151-7187. doi: 10.1039/d2ob00960a.
The hydroarylation of alkynes, alkenes, and allenes is a cost-effective and efficient way to incorporate unsaturated moieties into aromatic substrates. This review focuses on gold-catalyzed hydroarylation, which produces aromatic alkenes, diaryl-alkanes, heterocycles, carbocycles, and arylbutadienes by directly functionalizing C-H bonds. Without the need for prefunctionalization, direct functionalization of aromatic C-H bonds with unsaturated moieties (alkyne, alkene, allene) provides an efficient synthetic strategy with fewer reaction steps. This review offers an overview of the recently developed hydroarylation processes catalyzed by gold. Mechanisms of hydroarylation alkyne, alkene, allene, and arene activation receive special attention.
炔烃、烯烃和丙二烯的水合芳基化是将不饱和部分有效且高效地引入芳基底物的方法。本综述重点介绍金催化的水合芳基化反应，该反应通过直接官能化 C-H 键来生成芳基烯烃、二芳基烷烃、杂环、碳环和芳基丁二烯。通过不饱和部分（炔烃、烯烃、丙二烯）直接官能化芳基 C-H 键，无需预官能化，为具有较少反应步骤的反应提供了有效的合成策略。本综述概述了最近开发的金催化的水合芳基化反应。金催化的炔烃、烯烃、丙二烯和芳烃的水合芳基化反应的机理受到特别关注。
