Section for Colorectal Cancer Screening, Cancer Registry of Norway, Oslo, Norway.
Department of Research, Cancer Registry of Norway, Oslo, Norway.
Br J Nutr. 2023 Jun 28;129(12):2122-2132. doi: 10.1017/S0007114522002860. Epub 2022 Sep 7.
Limited data exist regarding the role of meat consumption in early-stage colorectal carcinogenesis. We examined associations of red and processed meat intake with screen-detected colorectal lesions in immunochemical fecal occult blood test (FIT)-positive participants, enrolled in the Norwegian CRCbiome study during 2017-2021, aged 55-77 years. Absolute and energy-adjusted intakes of red and processed meat (combined and individually) were assessed using a validated, semi-quantitative FFQ. Associations between meat intake and screen-detected colorectal lesions were examined using multinomial logistic regression analyses with adjustment for key covariates. Of 1162 participants, 319 presented with advanced colorectal lesions at colonoscopy. High . low energy-adjusted intakes of red and processed meat combined, as well as red meat alone, were borderline to significantly positively associated with advanced colorectal lesions (OR of 1·24 (95 % CI 0·98, 1·57) and 1·34 (95 % CI 1·07, 1·69), respectively). A significant dose-response relationship was also observed for absolute intake levels (OR of 1·32 (95 % CI 1·09, 1·60) per 100 g/d increase in red and processed meat). For processed meat, no association was observed between energy-adjusted intakes and advanced colorectal lesions. A significant positive association was, however, observed for participants with absolute intake levels ≥ 100 . < 50 g/d (OR of 1·19 (95 % CI 1·09, 1·31)). In summary, high intakes of red and processed meat were associated with presence of advanced colorectal lesions at colonoscopy in FIT-positive participants. The study demonstrates a potential role of dietary data to improve the performance of FIT-based screening.
关于肉类消费在结直肠肿瘤早期发生中的作用，现有数据有限。我们研究了在 2017-2021 年期间参加挪威 CRCbiome 研究的免疫化学粪便潜血试验（FIT）阳性、年龄在 55-77 岁的参与者中，红肉和加工肉类摄入与结肠镜检出的结直肠病变之间的关联。通过使用验证的半定量 FFQ 评估红肉和加工肉类（合并和单独）的绝对和能量调整摄入量。使用多变量逻辑回归分析，在调整关键协变量后，检查肉类摄入量与结肠镜检出的结直肠病变之间的关联。在 1162 名参与者中，319 名在结肠镜检查时发现晚期结直肠病变。高、低能量调整的红肉和加工肉类（合并和单独）摄入量与晚期结直肠病变呈边缘到显著正相关（OR 分别为 1.24（95%CI 0.98，1.57）和 1.34（95%CI 1.07，1.69））。绝对摄入量水平也观察到显著的剂量反应关系（OR 为 1.32（95%CI 1.09，1.60），每增加 100g/d 的红肉类和加工肉类）。对于加工肉类，能量调整摄入量与晚期结直肠病变之间没有关联。然而，对于绝对摄入量水平≥100 且 < 50g/d 的参与者，观察到与高级结直肠病变呈显著正相关（OR 为 1.19（95%CI 1.09，1.31））。总之，在 FIT 阳性参与者中，高摄入量的红肉和加工肉类与结肠镜检出的晚期结直肠病变相关。该研究表明，饮食数据有可能改善 FIT 为基础的筛查的性能。
