Rizzo Giuseppe, Pietrolucci Maria Elena, De Vito Marika, Pavjola Maqina, Capponi Alessandra, Mappa Ilenia
Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, University of Rome Tor Vergata, Rome, Italy.
Department of Obstetrics and Gynecology, Ospedale San Giovanni Rome, Rome, Italy.
J Clin Ultrasound. 2023 Jan;51(1):84-90. doi: 10.1002/jcu.23308. Epub 2022 Sep 7.
To evaluate brain biometry and cortical development by neurosonography in fetuses with congenital heart defect (CHD) and evaluate differences among different type of CHD.
In a prospective cross sectional study singleton fetus with CHD were matched with controls and grouped into two categories according to the predicted severity of cerebral arterial oxygen deficit induced by the CHD: Group A mildly reduced or normal and Group B moderately to severely reduced. Neurosonography was done at 30-33 weeks to obtain measurements of corpus callosum (CC), cerebellar vermis (CV), Sylvian fissure (SF) insula, parieto-occipital fissure (POF), and calcarine sulci fissures (CSF). All the neurosonographic parameters were adjusted by head circumference (HC).
A total of 78 fetuses with CHD (group A 30; group B 48) and 80 matched controls form uncomplicated pregnancies were considered. CHD fetuses have significantly smaller CC, CV, SF, and POF and bigger insula when compared to control fetuses. These differences are more marked in group B fetuses. These differences remained significant after correction for HC values.
Fetuses with CHD have an impaired cortical development and these variations are more evident in those with a predicted lower oxygen delivery to the brain.
通过超声检查评估先天性心脏病（CHD）胎儿的脑生物测量和皮质发育，并评估不同类型CHD之间的差异。
在一项前瞻性横断面研究中，将患有CHD的单胎胎儿与对照组进行匹配，并根据CHD引起的脑动脉氧缺乏的预测严重程度分为两类：A组轻度降低或正常，B组中度至重度降低。在孕30 - 33周进行超声检查，以测量胼胝体（CC）、小脑蚓部（CV）、外侧裂（SF）、脑岛、顶枕裂（POF）和距状沟（CSF）。所有超声参数均根据头围（HC）进行调整。
共纳入78例患有CHD的胎儿（A组30例；B组48例）和80例来自无并发症妊娠的匹配对照组。与对照胎儿相比，患有CHD 的胎儿的CC、CV、SF和POF明显较小，脑岛较大。这些差异在B组胎儿中更为明显。在校正HC值后，这些差异仍然显著。
患有CHD的胎儿皮质发育受损，并且这些差异在预测脑氧输送较低的胎儿中更为明显。
