Department of Obstetrics and Gynecology Fondazione Policlinico Tor Vergata, Università di Roma Tor Vergata, Rome, Italy.
Department of Obstetrics and Gynecology, Università Roma La Sapienza, Rome, Italy.
J Perinat Med. 2023 Aug 21;51(9):1212-1219. doi: 10.1515/jpm-2023-0176. Print 2023 Nov 27.
To develop charts for fetal brain cortical structures following a proposed standardized methodology and using quantile regression.
Prospective cross-sectional study including 344 low-risk singleton pregnancies between 19 and 34 weeks of gestation. The depth of Sylvian (SF), Parieto-occipital (POF) and Calcarine fissures (CF) were measured on ultrasound images using a standardized technique and their changes were evaluated by quantile regression as a function of gestational age (GA) interval or head circumference (HC).
The measurements of SF, POF and CF depth significantly increased with gestation. Linear models better described the changes of cortical variables with GA and HC. When the fit of sulci depth with GA and HC were compared, a close relationship was highlighted for the latter variable.
We provided prospective charts of fetal cortical development using quantile regression and following a strict standardized methodology These new charts may help in better identifying cases at higher risk of abnormal cortical neurodevelopment.
使用分位数回归方法，按照既定的标准化方案，制定胎儿大脑皮质结构图表。
本前瞻性横断面研究纳入了 344 例孕龄 19 至 34 周的低危单胎妊娠。使用标准化技术，在超声图像上测量外侧裂（SF）、顶枕裂（POF）和距状裂（CF）的深度，并通过分位数回归评估其随孕龄（GA）间隔或头围（HC）的变化。
SF、POF 和 CF 深度的测量值随孕龄显著增加。线性模型更好地描述了皮质变量随 GA 和 HC 的变化。当比较脑回深度与 GA 和 HC 的拟合情况时，后者的相关性更强。
我们使用分位数回归和严格的标准化方法提供了胎儿皮质发育的前瞻性图表。这些新图表可能有助于更好地识别皮质神经发育异常风险较高的病例。
