College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China.
Shenzhen Longhua Maternity and Childcare Hospital, Shenzhen, China.
J Mater Chem B. 2022 Oct 5;10(38):7760-7771. doi: 10.1039/d2tb01276f.
Phototherapy, which mainly includes photothermal therapy (PTT) and photodynamic therapy (PDT), is one of the most promising strategies for cancer therapeutics. Ruthenium as a metal nanomaterial shows great potential as a phototherapy agent. Herein, we developed flower-like ruthenium nanoparticles (FRuNPs) to enhance cancer phototherapy. Compared with spherical ruthenium nanoparticles (SRuNPs) of a similar size, FRuNPs exhibited more enhanced near-infrared (NIR) absorption. FRuNPs exhibited a superior photothermal effect, which significantly improved the efficiency of PTT. Intracellular reactive oxide species (ROS) generation was recognized as the primary mechanism of PDT treatment. FRuNPs mediated the generation of ROS when exposed to 808 nm laser irradiation. Moreover, with the synergistic effect of PTT and PDT in FRuNPs, the phototherapeutic effects were obviously enhanced. phototherapy of MCF-7 cells in the presence of FRuNPs led to nearly 100% cell death under irradiation with an 808 nm laser. And FRuNPs further showed the capacity of in completely clearing the tumor tissues and improving the hypoxia environment with 14 days for interval laser irradiation. These results indicate that FRuNPs have versatile potential for tumor phototherapy.
光疗主要包括光热疗法（PTT）和光动力疗法（PDT），是癌症治疗中最有前途的策略之一。钌作为一种金属纳米材料，作为光疗剂显示出巨大的潜力。在此，我们开发了类花状钌纳米粒子（FRuNPs）以增强癌症光疗。与类似尺寸的球形钌纳米粒子（SRuNPs）相比，FRuNPs 表现出更强的近红外（NIR）吸收。FRuNPs 表现出优异的光热效应，显著提高了 PTT 的效率。细胞内活性氧（ROS）的产生被认为是 PDT 治疗的主要机制。当 FRuNPs 暴露于 808nm 激光照射时，会介导 ROS 的产生。此外，在 FRuNPs 中 PTT 和 PDT 的协同作用下，光疗效果明显增强。在 808nm 激光照射下，FRuNPs 对 MCF-7 细胞的光疗导致近 100%的细胞死亡。并且 FRuNPs 进一步显示出在 14 天的间隔激光照射下完全清除肿瘤组织和改善缺氧环境的能力。这些结果表明 FRuNPs 具有多功能的肿瘤光疗潜力。
