Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners.

An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp)-N bonds has been achieved. This methodology proceeds under metal-free and exogenous oxidant-free conditions producing N and H as byproducts. Mechanistic studies reveal the generations of both acyl and -centered radicals from benzoyl hydrazines and amines. The utility of this protocol is demonstrated through a large-scale, and synthesis of bezafibrate, a hyperlipidemic drug.