文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

帕金森病中的失眠:病因、后果及治疗方法

Insomnia in Parkinson's Disease: Causes, Consequences, and Therapeutic Approaches.

作者信息

Duan Xiaoyu, Liu Hanshu, Hu Xinyu, Yu Qinwei, Kuang Guiying, Liu Long, Zhang Shurui, Wang Xinyi, Li Jingwen, Yu Danfang, Huang Jinsha, Wang Tao, Lin Zhicheng, Xiong Nian

机构信息

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Duke Kunshan University, No. 8 Duke Avenue, Kunshan, 215316, Jiangsu, China.

出版信息

Mol Neurobiol. 2025 Feb;62(2):2292-2313. doi: 10.1007/s12035-024-04400-4. Epub 2024 Aug 5.


DOI:10.1007/s12035-024-04400-4
PMID:39103716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11772535/
Abstract

Sleep disorders represent prevalent non-motor symptoms in Parkinson's disease (PD), affecting over 90% of the PD population. Insomnia, characterized by difficulties in initiating and maintaining sleep, emerges as the most frequently reported sleep disorder in PD, with prevalence rates reported from 27 to 80% across studies. Insomnia not only significantly impacts the quality of life of PD patients but is also associated with cognitive impairment, motor disabilities, and emotional deterioration. This comprehensive review aims to delve into the mechanisms underlying insomnia in PD, including neurodegenerative changes, basal ganglia beta oscillations, and circadian rhythms, to gain insights into the neural pathways involved. Additionally, the review explores the risk factors and comorbidities associated with insomnia in PD, providing valuable insights into its management. Special attention is given to the challenges faced by healthcare providers in delivering care to PD patients and the impact of caregiving roles on patients' quality of life. Overall, this review provides a comprehensive understanding of insomnia in PD and highlights the importance of addressing this common sleep disorder in PD patients.

摘要

睡眠障碍是帕金森病(PD)中普遍存在的非运动症状,影响超过90%的帕金森病患者。失眠的特征是入睡和维持睡眠困难,是帕金森病中最常报告的睡眠障碍,各研究报告的患病率在27%至80%之间。失眠不仅显著影响帕金森病患者的生活质量,还与认知障碍、运动残疾和情绪恶化有关。这篇综述旨在深入探讨帕金森病中失眠的潜在机制,包括神经退行性变化、基底神经节β振荡和昼夜节律,以深入了解其中涉及的神经通路。此外,该综述还探讨了与帕金森病失眠相关的风险因素和合并症,为其管理提供了有价值的见解。特别关注了医疗保健提供者在为帕金森病患者提供护理时面临的挑战以及护理角色对患者生活质量的影响。总体而言,这篇综述全面阐述了帕金森病中的失眠问题,并强调了解决帕金森病患者这一常见睡眠障碍的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/4931d06219a0/12035_2024_4400_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/5131506bed4e/12035_2024_4400_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/4e4c9bd16ba0/12035_2024_4400_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/35af013b146e/12035_2024_4400_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/4931d06219a0/12035_2024_4400_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/5131506bed4e/12035_2024_4400_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/4e4c9bd16ba0/12035_2024_4400_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/35af013b146e/12035_2024_4400_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8698/11772535/4931d06219a0/12035_2024_4400_Fig4_HTML.jpg

相似文献

[1]
Insomnia in Parkinson's Disease: Causes, Consequences, and Therapeutic Approaches.

Mol Neurobiol. 2025-2

[2]
Etiologies of insomnia in Parkinson's disease - Lessons from human studies and animal models.

Exp Neurol. 2022-4

[3]
[Sleep disorders in Parkinson's disease: insomnia and sleep fragmentation, daytime hypersomnia, alterations to the circadian rhythm and sleep apnea syndrome].

Rev Neurol. 2010-2-8

[4]
Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia.

Proc Natl Acad Sci U S A. 2020-7-21

[5]
[Sleep disturbances in Parkinson's disease: characteristics, evaluation and therapeutic approaches].

Orv Hetil. 2015-7-5

[6]
[Insomnia comorbid to Parkinson's disease Part I: Epidemiology, assessment, and related factors].

Geriatr Psychol Neuropsychiatr Vieil. 2020-9-1

[7]
[Insomnia comorbid to Parkinson's disease Part II: Therapeutic approaches].

Geriatr Psychol Neuropsychiatr Vieil. 2020-9-1

[8]
Sleep-Related Disorders in Parkinson's Disease: Mechanisms, Diagnosis, and Therapeutic Approaches.

CNS Neurol Disord Drug Targets. 2025

[9]
Insomnia in central neurologic diseases--occurrence and management.

Sleep Med Rev. 2011-4-9

[10]
Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship.

Mov Disord Clin Pract. 2025-1

引用本文的文献

[1]
Identification of SNCA and DRD2 as key genes linking parkinson's disease and circadian rhythm through bioinformatics analysis.

Sci Rep. 2025-8-26

[2]
Neuropsychiatric disorders in Parkinson's disease.

Ther Adv Neurol Disord. 2025-7-28

[3]
Redefining Non-Motor Symptoms in Parkinson's Disease.

J Pers Med. 2025-4-26

[4]
Research hotspots and future trends of insomnia in Parkinson's disease: a bibliometric and visualization analysis from 1973 to 2024.

Front Aging Neurosci. 2025-5-9

[5]
From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson's Disease.

J Multidiscip Healthc. 2025-1-30

本文引用的文献

[1]
Sleep disorders in Parkinson's disease, an early and multiple problem.

NPJ Parkinsons Dis. 2024-2-29

[2]
Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS).

Sleep Med. 2024-3

[3]
Sleep features and long-term incident neurodegeneration: a polysomnographic study.

Sleep. 2024-3-11

[4]
Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses.

J Pers Med. 2023-10-12

[5]
Significant potential of melatonin therapy in Parkinson's disease - a meta-analysis of randomized controlled trials.

Front Neurol. 2023-10-10

[6]
Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance.

Nat Commun. 2023-9-5

[7]
The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep.

Biomedicines. 2023-7-25

[8]
Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury.

Front Aging Neurosci. 2023-8-4

[9]
Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases.

Encephalitis. 2023-4

[10]
Clinical Evaluation of Sleep Disorders in Parkinson's Disease.

Brain Sci. 2023-4-3

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索