Duan Xiaoyu, Liu Hanshu, Hu Xinyu, Yu Qinwei, Kuang Guiying, Liu Long, Zhang Shurui, Wang Xinyi, Li Jingwen, Yu Danfang, Huang Jinsha, Wang Tao, Lin Zhicheng, Xiong Nian
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Duke Kunshan University, No. 8 Duke Avenue, Kunshan, 215316, Jiangsu, China.
Mol Neurobiol. 2025 Feb;62(2):2292-2313. doi: 10.1007/s12035-024-04400-4. Epub 2024 Aug 5.
Sleep disorders represent prevalent non-motor symptoms in Parkinson's disease (PD), affecting over 90% of the PD population. Insomnia, characterized by difficulties in initiating and maintaining sleep, emerges as the most frequently reported sleep disorder in PD, with prevalence rates reported from 27 to 80% across studies. Insomnia not only significantly impacts the quality of life of PD patients but is also associated with cognitive impairment, motor disabilities, and emotional deterioration. This comprehensive review aims to delve into the mechanisms underlying insomnia in PD, including neurodegenerative changes, basal ganglia beta oscillations, and circadian rhythms, to gain insights into the neural pathways involved. Additionally, the review explores the risk factors and comorbidities associated with insomnia in PD, providing valuable insights into its management. Special attention is given to the challenges faced by healthcare providers in delivering care to PD patients and the impact of caregiving roles on patients' quality of life. Overall, this review provides a comprehensive understanding of insomnia in PD and highlights the importance of addressing this common sleep disorder in PD patients.
睡眠障碍是帕金森病（PD）中普遍存在的非运动症状，影响超过90%的帕金森病患者。失眠的特征是入睡和维持睡眠困难，是帕金森病中最常报告的睡眠障碍，各研究报告的患病率在27%至80%之间。失眠不仅显著影响帕金森病患者的生活质量，还与认知障碍、运动残疾和情绪恶化有关。这篇综述旨在深入探讨帕金森病中失眠的潜在机制，包括神经退行性变化、基底神经节β振荡和昼夜节律，以深入了解其中涉及的神经通路。此外，该综述还探讨了与帕金森病失眠相关的风险因素和合并症，为其管理提供了有价值的见解。特别关注了医疗保健提供者在为帕金森病患者提供护理时面临的挑战以及护理角色对患者生活质量的影响。总体而言，这篇综述全面阐述了帕金森病中的失眠问题，并强调了解决帕金森病患者这一常见睡眠障碍的重要性。
