SRM Institute of Science and Technology, Kattankulathur, India.
Arch Environ Contam Toxicol. 2022 Oct;83(3):201-213. doi: 10.1007/s00244-022-00955-2. Epub 2022 Sep 7.
Zebrafish (Danio rerio) is an increasingly popular vertebrate model used for assessing the toxicity of endocrine-disrupting chemicals (EDCs) on living beings. The zebrafish features high genetic homology to mammals, because of its rapid embryonic development, optical transparency of phenotypic screening embryos, high throughput genetic and chemical screening which make them a powerful toxicological model. This systematic review aimed to assess the recent literature on the use of zebrafish model in EDCs toxicity studies. We capture the data on the types of EDCs used, zebrafish life stages associated with the toxicity, and its effects on the alterations in neuroendocrine factors and cardiac hypoxia in zebrafish. A total of 17 articles published between 2010 and 2020 were curated. The information gathered highlighted the association of EDCs with cardiological outcomes and neurobehavioral effects and distorted expression of genes. The genes that were highlighted in the paper include bdnf, ntrk2a, grin2cb, VTG-1, HIF-1α, tnnt2, ntrk1, and pax6b. The effect of EDCs on cardiac hypoxia and neurodevelopmental and behavioral factors of zebrafish were described in all the papers chosen for this review. The involvement of EDCs in altered regulation of gene expression can be studied further to identify the potential EDC compounds on its toxicological and endocrine disruption function at the molecular level.
斑马鱼（Danio rerio）是一种越来越受欢迎的脊椎动物模型，用于评估内分泌干扰化学物质（EDCs）对生物的毒性。由于其胚胎发育迅速、表型筛选胚胎的光学透明度、高通量遗传和化学筛选，斑马鱼与哺乳动物具有高度的遗传同源性，使其成为一种强大的毒理学模型。本系统评价旨在评估关于斑马鱼模型在 EDC 毒性研究中应用的最新文献。我们获取了有关使用的 EDC 类型、与毒性相关的斑马鱼生命阶段以及其对神经内分泌因子和心脏缺氧改变的影响的数据。共整理了 2010 年至 2020 年期间发表的 17 篇文章。收集到的信息强调了 EDCs 与心脏疾病结果和神经行为效应的关联，以及基因表达的扭曲。本文强调的基因包括 bdnf、ntrk2a、grin2cb、VTG-1、HIF-1α、tnnt2、ntrk1 和 pax6b。所有选择用于本综述的论文都描述了 EDCs 对心脏缺氧以及斑马鱼神经发育和行为因素的影响。可以进一步研究 EDCs 对基因表达的调节改变，以确定潜在的 EDC 化合物在分子水平上的毒理学和内分泌干扰功能。
