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恒河猴中由新冠灭活疫苗和 S1 亚单位疫苗引发的不同 T 细胞和 B 细胞反应。

Different T-cell and B-cell repertoire elicited by the SARS-CoV-2 inactivated vaccine and S1 subunit vaccine in rhesus macaques.

机构信息

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People's Republic of China.

Grade 11, Kunming No.1 High School, Kunming 650031, People's Republic of China.

出版信息

Hum Vaccin Immunother. 2022 Nov 30;18(6):2118477. doi: 10.1080/21645515.2022.2118477. Epub 2022 Sep 7.

DOI:10.1080/21645515.2022.2118477
PMID:36070519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9746386/
Abstract

Multiple types of SARS-CoV-2 vaccines have been used worldwide, but summarizing their immunologic efficacy post-vaccination remains challenging. The BCR and TCR sequencing based on single-cell sorting makes it possible to evaluate the vaccine-induced immune responses of B or T cells. In this study, we compared the repertoire diversities of B cells and T cells between a whole-virus inactivated vaccine and an S1 protein subunit vaccine in rhesus macaques. We found that the inactivated vaccine could induce a large antigen-specific-BCR repertoire with longer VH CDR3 (21 aa), while the CD3+ TCR α chains of the two vaccine groups showed a similar TCRV/J usage frequency. Detailed analysis of the TCR and BCR repertoires might be of interest for further understanding of the mechanisms of vaccine-induced immune responses.

摘要

多种类型的 SARS-CoV-2 疫苗已在全球范围内使用，但总结其接种后的免疫效力仍然具有挑战性。基于单细胞分选的 BCR 和 TCR 测序使得评估 B 细胞或 T 细胞的疫苗诱导免疫反应成为可能。在这项研究中，我们比较了恒河猴全病毒灭活疫苗和 S1 蛋白亚单位疫苗诱导的 B 细胞和 T 细胞库的多样性。我们发现，灭活疫苗可以诱导具有较长 VH CDR3（21 个氨基酸）的大抗原特异性 BCR 库，而两组疫苗的 CD3+TCRα链显示出相似的 TCRV/J 使用频率。TCR 和 BCR 库的详细分析可能有助于进一步了解疫苗诱导免疫反应的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/03246fcb9b10/KHVI_A_2118477_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/ba150f29266e/KHVI_A_2118477_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/20d962d00125/KHVI_A_2118477_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/03246fcb9b10/KHVI_A_2118477_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/ba150f29266e/KHVI_A_2118477_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/20d962d00125/KHVI_A_2118477_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4448/9746386/03246fcb9b10/KHVI_A_2118477_F0003_OC.jpg

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Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals.
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