COVID-19 现代疫苗接种后出现肌痛的中等血管血管炎。

Department of Rheumatology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Department of Pathology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Intern Med. 2022 Nov 15;61(22):3453-3457. doi: 10.2169/internalmedicine.0293-22. Epub 2022 Sep 6.

Coronavirus disease 2019 (COVID-19) vaccines have been delivered worldwide to prevent the spread of the disease, and almost all Japanese have received the mRNA vaccines "BNT162b2" (Pfizer-BioNTech) or "mRNA-1273" (Moderna). These vaccines have shown efficacy and safety with only minor adverse drug reactions. However, some patients develop severe adverse drug reactions, including autoimmune reactions. In addition, systemic vasculitis, mainly small-vessel vasculitis, following COVID-19 vaccination, has been reported. However, only a few investigators have reported medium-vessel vasculitis following vaccination. We herein report a case of medium-vessel vasculitis presenting with myalgia as the initial clinical manifestation following COVID-19 Moderna vaccination.

新型冠状病毒病 2019（COVID-19）疫苗已在全球范围内分发，以防止疾病传播，几乎所有日本人都接种了信使 RNA 疫苗“BNT162b2”（辉瑞-生物科技）或“mRNA-1273”（莫德纳）。这些疫苗仅出现轻微药物不良反应，显示出疗效和安全性。然而，一些患者出现严重的药物不良反应，包括自身免疫反应。此外，COVID-19 疫苗接种后还会出现系统性血管炎，主要是小血管血管炎。然而，只有少数研究人员报告了接种疫苗后中等大小血管炎。我们在此报告了一例中等大小血管炎病例，其临床表现为 COVID-19 Moderna 疫苗接种后出现肌痛。