异基因骨髓移植治疗慢性髓性白血病急变后出现抗 MDA-5 抗体阳性皮肌炎。
Anti-MDA-5 Antibody-positive Dermatomyositis after Allogeneic Bone Marrow Transplantation for Acute Transformation of Chronic Myelogenous Leukemia.
机构信息
Department of Rheumatology and Clinical Immunology, Kansai Medical University Hospital, Japan.
First Department of Internal Medicine, Kansai Medical University, Japan.
出版信息
Intern Med. 2023 Apr 1;62(7):1081-1087. doi: 10.2169/internalmedicine.9529-22. Epub 2022 Sep 6.
Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody-positive dermatomyositis is a disease with a poor prognosis associated with rapid progressive interstitial pneumonia. Autoimmune diseases have occasionally been reported to occur after hematopoietic stem cell transplantation (HSCT). We experienced a case of anti-MDA-5 antibody-positive dermatomyositis after HSCT. In this case, a sufficient dose of cyclophosphamide could not be administered due to an impaired bone marrow function. We discuss the complications of autoimmune diseases after HSCT.
抗黑色素瘤分化相关基因 5（MDA-5）抗体阳性皮肌炎是一种预后不良的疾病，与快速进展性间质性肺炎相关。自身免疫性疾病在造血干细胞移植（HSCT）后偶尔有报道。我们经历了一例 HSCT 后抗 MDA-5 抗体阳性皮肌炎的病例。在这种情况下，由于骨髓功能受损，无法给予足够剂量的环磷酰胺。我们讨论了 HSCT 后自身免疫性疾病的并发症。
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