Zubenko G S, Malinakova I, Cohen B M
Biol Psychiatry. 1987 Aug;22(8):987-94. doi: 10.1016/0006-3223(87)90008-4.
The biophysical properties of platelet membranes from five patients with Alzheimer-type dementia and five neurologically healthy controls, matched for age and sex, were examined by fluorescence spectroscopy employing the fluorescent probes DPH and TMADPH. The anisotropy of DPH has previously been observed to be reduced in platelet membranes of patients with Alzheimer-type dementia. However, Alzheimer's disease was not associated with a significant change in the flow activation energy at either deep or superficial regions of platelet membranes. In addition, the temperature-dependent phase transition observed with TMADPH occurred at the same mean temperature in platelet membranes from the demented and control groups.
采用荧光探针DPH和TMADPH，通过荧光光谱法检测了5例阿尔茨海默病型痴呆患者和5例年龄与性别相匹配的神经健康对照者的血小板膜生物物理特性。此前观察到，阿尔茨海默病型痴呆患者血小板膜中DPH的各向异性降低。然而，阿尔茨海默病与血小板膜深层或表层区域的流动活化能显著变化无关。此外，痴呆组和对照组血小板膜中用TMADPH观察到的温度依赖性相变发生在相同的平均温度。
