Zubenko G S, Cohen B M, Reynolds C F, Boller F, Malinakova I, Keefe N
Am J Psychiatry. 1987 Jul;144(7):860-8. doi: 10.1176/ajp.144.7.860.
Double-blind fluorescence studies of platelet membrane fluidity were conducted at 37 degrees C for 51 patients with Alzheimer-type dementia, 24 nondemented depressed patients, and 50 neurologically healthy subjects. The fluidity of the hydrocarbon region of platelet membranes from the demented group, as reflected by the steady-state anisotropy of the fluorescent probe 1,6-diphenyl-1,3,5-hexatriene (DPH), was significantly greater than that for the depressed and normal control subjects. Within the demented group, platelet membrane fluidity was significantly correlated with severity of dementia but not with duration of illness or age at onset. Demented patients with "increased" platelet membrane fluidity had an earlier onset, were more severely demented, and deteriorated more rapidly.
在37摄氏度下，对51例阿尔茨海默型痴呆患者、24例无痴呆的抑郁症患者和50名神经功能正常的受试者进行了血小板膜流动性的双盲荧光研究。痴呆组血小板膜碳氢化合物区域的流动性，通过荧光探针1,6 - 二苯基 - 1,3,5 - 己三烯（DPH）的稳态各向异性反映，显著高于抑郁症患者和正常对照组。在痴呆组中，血小板膜流动性与痴呆严重程度显著相关，但与病程或发病年龄无关。血小板膜流动性“增加”的痴呆患者发病更早，痴呆程度更严重，病情恶化更快。
