Al-Numair Nouf S, Theyab Abdulrahman, Alzahrani Faisal, Shams Anwar M, Al-Anazi Ibrahim O, Oyouni Atif Abdulwahab A, Al-Amer Osama M, Mavromatis Charalampos, Saadeldin Islam M, Abdali Wed A, Hawsawi Yousef M
Center of Genomic Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia.
Cancer Cell Int. 2022 Sep 7;22(1):279. doi: 10.1186/s12935-022-02696-7.
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels' biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.
癌症是一个主要的健康问题，是全球主要死因之一。需要创新策略来辅助不同类型癌症的诊断和治疗。最近，人们越来越关注利用骆驼源纳米抗体作为抗癌治疗工具。纳米技术利用纳米抗体，这是一个新兴的有吸引力的领域，为包括医学和肿瘤学在内的不同科学领域的研究人员带来了希望。纳米抗体是一种特殊的小型生物制剂，具有深入组织渗透和扩散的能力，并且在高pH值和温度下具有高稳定性。本综述强调了骆驼生物体液（牛奶和尿液）中天然分泌的纳米抗体在开发基于纳米技术的疗法以治疗不同类型癌症和其他疾病方面的潜在用途。此外，还阐述了纳米蛋白质组学在发明专门用于癌症干预的新型治疗剂中的作用。
