Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Paediatr Perinat Epidemiol. 2023 Jan;37(1):57-68. doi: 10.1111/ppe.12924. Epub 2022 Sep 7.
Little is known about potential health effects of eating organic food in relation to reproduction.
We examined associations between organic food consumption and fecundability.
Data were derived from a preconception cohort study of Danish couples trying to conceive (SnartForaeldre.dk, SF). Participants completed a baseline questionnaire on socio-demographics, anthropometrics and lifestyle and a validated food-frequency questionnaire, which included questions on proportions of organic food consumed within six food groups. Participants were followed up with bimonthly questionnaires for up to 12 months or until pregnancy. Analyses were restricted to 2061 participants attempting pregnancy for ≤6 cycles at enrollment and 1303 with <3 cycles. Fecundability ratios (FRs) and 95% confidence intervals (CI) were estimated by proportional probabilities regression models adjusted for potential confounders including age, lifestyle and socioeconomic factors. Associations were examined for vegetables, fruits, cereals, dairy products, eggs and meat, separately, and for the overall pattern of organic food consumption (organic sum score).
The final analytic sample comprised 2069 participants. In the full cohort, organic food consumption was not meaningfully associated with fecundability. Among participants <3 cycles of pregnancy attempt at study entry (n = 1303), the FR was 1.11 (95% CI 0.93, 1.33) for the category 'less than half', for 'more than half' the FR was 1.17 (95% CI 0.99, 1.38) and for 'almost everything' the FR was 1.12 (95% CI 0.97, 1.28).
Higher consumption of organic foods was not meaningfully associated with fecundability, although slightly greater fecundability was seen among participants with <3 cycles of pregnancy attempt time.
关于食用有机食品与生殖相关的潜在健康影响知之甚少。
我们研究了有机食品消费与生育能力之间的关系。
数据来自丹麦夫妇生育力预研究队列（SnartForaeldre.dk，SF）。参与者完成了一份关于社会人口统计学、人体测量学和生活方式以及一份经过验证的食物频率问卷的基线问卷，该问卷包括在六个食物组中食用有机食品的比例问题。参与者在登记后的最多 12 个月或怀孕前每两个月接受一次随访问卷。分析仅限于在登记时尝试怀孕不超过 6 个周期的 2061 名参与者和尝试怀孕<3 个周期的 1303 名参与者。使用比例概率回归模型调整潜在混杂因素（包括年龄、生活方式和社会经济因素）来估计生育能力比值（FRs）和 95%置信区间（CI）。分别对蔬菜、水果、谷物、奶制品、鸡蛋和肉类进行了研究，并对有机食品消费的整体模式（有机总和评分）进行了研究。
最终分析样本包括 2069 名参与者。在整个队列中，有机食品消费与生育能力无明显关联。在研究开始时怀孕尝试<3 个周期的参与者中（n=1303），“少于一半”类别中的 FR 为 1.11（95%CI 0.93，1.33），“多于一半”类别的 FR 为 1.17（95%CI 0.99，1.38），“几乎所有”类别的 FR 为 1.12（95%CI 0.97，1.28）。
更高的有机食品消费与生育能力无明显关联，尽管怀孕尝试<3 个周期的参与者生育能力略有提高。
