Su Yuanhao, Mei Lin, Jiang Tiantian, Wang Zhidong, Ji Yuanyuan
Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong, University, Xi'an, 710004, China.
Scientific Research Center and Precision Medical Institute, The Second Affiliated, Hospital, Xi'an Jiaotong University, Xi'an, 710004, China.
Biochem Biophys Rep. 2024 Feb 29;38:101674. doi: 10.1016/j.bbrep.2024.101674. eCollection 2024 Jul.
Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The incidence of PTC has increased annually worldwide. Thus, PTC diagnosis and treatment attract more attention. Noncoding RNAs (lncRNAs) play crucial roles in PTC progression and act as prognostic biomarkers. Moreover, microRNAs (miRNAs) and epithelial-mesenchymal transition (EMT)-associated proteins have potential biomarkers for diagnosing and treating PTC. However, the correlation of lncRNAs with miRNAs and EMT-associated proteins needs further clarification. The present review highlights the recent advances of lncRNAs in PTC. We significantly summarized the two molecular regulatory mechanisms in PTC progress, including lncRNAs-miRNAs-protein signaling axes and lncRNAs-EMT pathways. This review will help our understanding of the association between lncRNAs and PTC and may assist us in evaluating the prognosis for PTC patients. Taken together, targeting the lncRNAs regulatory network has promising applications in diagnosing and treating PTC.
甲状腺乳头状癌（PTC）是最常见的内分泌恶性肿瘤。全球范围内，PTC的发病率逐年上升。因此，PTC的诊断和治疗备受关注。非编码RNA（lncRNA）在PTC进展中起关键作用，并可作为预后生物标志物。此外，微小RNA（miRNA）和上皮-间质转化（EMT）相关蛋白是诊断和治疗PTC的潜在生物标志物。然而，lncRNA与miRNA以及EMT相关蛋白之间的相关性仍需进一步阐明。本综述重点介绍了lncRNA在PTC方面的最新进展。我们显著总结了PTC进展中的两种分子调控机制，包括lncRNA-miRNA-蛋白质信号轴和lncRNA-EMT途径。本综述将有助于我们理解lncRNA与PTC之间的关联，并可能有助于我们评估PTC患者的预后。综上所述，靶向lncRNA调控网络在PTC的诊断和治疗中具有广阔的应用前景。
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