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靶向食管鳞状细胞癌中异常的组蛋白转录后修饰机制：当前研究结果与挑战

Targeting Aberrant Histone Posttranscription Modification Machinery in Esophageal Squamous Cell Carcinoma: Current Findings and Challenges.

作者信息

Ma Gang, Gong Tongyang, Liu Zhihua

机构信息

Department of Gastric Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

出版信息

Research (Wash D C). 2022 Aug 17;2022:9814607. doi: 10.34133/2022/9814607. eCollection 2022.

DOI:10.34133/2022/9814607
PMID:36072272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9422329/
Abstract

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy, but the survival rates of patients with ESCC have not improved as yet largely because the available targeted therapies are limited. Histone posttranscription modification (PTM) is a critical epigenetic regulation. Several deregulations in histone PTM machinery have been identified to promote malignant phenotypes of ESCC, providing druggable targets in treating ESCC. Hereby, we briefly describe current progress and challenges ahead in this field.

摘要

食管鳞状细胞癌（ESCC）是一种侵袭性恶性肿瘤，但ESCC患者的生存率尚未得到显著提高，这主要是因为现有的靶向治疗方法有限。组蛋白转录后修饰（PTM）是一种关键的表观遗传调控。已发现组蛋白PTM机制中的几种失调会促进ESCC的恶性表型，为ESCC治疗提供了可成药靶点。在此，我们简要描述该领域目前的进展和面临的挑战。