Zhuang Jingwen, Hang Ruiyue, Sun Ruoyue, Ding Yanshu, Yao Xiaohong, Hang Ruiqiang, Sun Hui, Bai Long
Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, China.
Front Chem. 2022 Aug 22;10:984131. doi: 10.3389/fchem.2022.984131. eCollection 2022.
Bone marrow mesenchymal stem cells (BMSCs) have self-renewal, multi-directional differentiation potential, and immune regulation function and are widely used for bone formation. However, the wide variation in individual amplification, the potential risk of cancer cell contamination, and the need for culture time significantly limit their widespread use clinically. Alternatively, numerous studies have shown that exosomes secreted by BMSCs in the nanoscale can also affect the functionality of endothelial cells (angiogenesis), macrophages (immunomodulation), and osteoblasts/osteoclasts (osteogenesis), which is a highly promising therapy for osseointegration with pronounced advantages (e.g., safety, high efficiency, and no ethical restrictions). The review aims to summarize the multifaceted effect of BMSCs-derived exosomes on osseointegration and provide reference and basis for rapid and qualified osseointegration.
骨髓间充质干细胞（BMSCs）具有自我更新、多向分化潜能和免疫调节功能，广泛应用于骨形成。然而，个体扩增的广泛差异、癌细胞污染的潜在风险以及培养时间的需求显著限制了它们在临床上的广泛应用。另外，大量研究表明，BMSCs分泌的纳米级外泌体也能影响内皮细胞（血管生成）、巨噬细胞（免疫调节）和成骨细胞/破骨细胞（骨生成）的功能，这是一种极具前景的骨整合治疗方法，具有明显优势（如安全性高、效率高且无伦理限制）。本综述旨在总结BMSCs来源的外泌体对骨整合的多方面影响，为快速且高质量的骨整合提供参考和依据。
