Shi Jiaqi, Yang Ning, Han Mingzhi, Qiu Chen
School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
Front Oncol. 2022 Aug 22;12:993316. doi: 10.3389/fonc.2022.993316. eCollection 2022.
Glioma is the most common primary malignant tumor in the central nervous system, and directly affects the quality of life and cognitive function of patients. Ferroptosis, is a new form of regulated cell death characterized by iron-dependent lipid peroxidation. Ferroptosis is mainly due to redox imbalance and involves multiple intracellular biology processes, such as iron metabolism, lipid metabolism, and antioxidants synthesis. Induction of ferroptosis could be a new target for glioma treatment, and ferroptosis-related processes are associated with chemoresistance and radioresistance in glioma. In the present review, we provide the characteristics, key regulators and pathways of ferroptosis and the crosstalk between ferroptosis and other programmed cell death in glioma, we also proposed the application and prospect of ferroptosis in the treatment of glioma.
胶质瘤是中枢神经系统中最常见的原发性恶性肿瘤，直接影响患者的生活质量和认知功能。铁死亡是一种新的程序性细胞死亡形式，其特征是铁依赖性脂质过氧化。铁死亡主要是由于氧化还原失衡，涉及多个细胞内生物学过程，如铁代谢、脂质代谢和抗氧化剂合成。诱导铁死亡可能是胶质瘤治疗的新靶点，并且铁死亡相关过程与胶质瘤的化疗耐药性和放疗抵抗性有关。在本综述中，我们阐述了铁死亡的特征、关键调节因子和途径，以及铁死亡与胶质瘤中其他程序性细胞死亡之间的相互作用，我们还提出了铁死亡在胶质瘤治疗中的应用和前景。
