Department of Immunology, School of Medicine, Nantong University, Nantong 226001, China.
Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226019, China.
Genes (Basel). 2023 Jul 6;14(7):1406. doi: 10.3390/genes14071406.
is a copy number amplification gene that promotes tumorigenesis. However, the clinical relevance and potential mechanisms of in glioma are unclear. expression level data were obtained from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases, and the enriched genes and related signaling pathways were explored. Data on genes in -related signaling pathways and nine marker genes of ferroptosis were retrieved and a protein-protein interaction (PPI) network analysis was performed. The correlation of to ferroptosis and tumor infiltration of 22 kinds of human immune cells and the association between and immune checkpoint molecules were analyzed. was significantly increased in gliomas in comparison to healthy tissues. Gene Ontology (GO) and gene set enrichment analysis (GSEA) revealed the impact of expression on multiple biological processes and signaling pathways. may affect ferroptosis by interacting with genes in the cell cycle pathway and P53 pathway. The increase in was positively correlated with multiple ferroptosis suppressor genes and genes involved in tumor-infiltrating immune cells and immune checkpoint molecules in glioma. can be a new prognostic factor for glioma, which is closely related to ferroptosis, tumor immune cell infiltration, and immune checkpoint.
是一个促进肿瘤发生的拷贝数扩增基因。然而，在神经胶质瘤中， 的临床相关性和潜在机制尚不清楚。从中国脑胶质瘤基因组图谱（CGGA）和癌症基因组图谱（TCGA）数据库中获取 表达水平数据，并探索富集的基因和相关信号通路。检索与 - 相关信号通路相关的基因和铁死亡的九个标记基因，并进行蛋白质-蛋白质相互作用（PPI）网络分析。分析 与铁死亡和 22 种人类免疫细胞浸润肿瘤的相关性，以及 与免疫检查点分子的相关性。与健康组织相比， 在神经胶质瘤中显著增加。基因本体论（GO）和基因集富集分析（GSEA）揭示了 表达对多种生物学过程和信号通路的影响。 可能通过与细胞周期途径和 P53 途径中的基因相互作用来影响铁死亡。 在神经胶质瘤中的增加与多种铁死亡抑制基因以及参与肿瘤浸润免疫细胞和免疫检查点分子的基因呈正相关。 可以成为神经胶质瘤的一个新的预后因素，它与铁死亡、肿瘤免疫细胞浸润和免疫检查点密切相关。
