Postgraduate Program in Dentistry, University of Brasília, Brasília, Brazil.
Faculty of Health Sciences, Dentistry Department, University of Brasília, Brasília, Brazil.
Ann Med. 2022 Dec;54(1):1908-1917. doi: 10.1080/07853890.2022.2092895.
Characterise oral health, and the presence in the oral cavity of pathogenic non-oral microorganisms potentially associated with nosocomial infections and antimicrobial resistance in non-intubated patients admitted to a Brazilian university hospital.
An intraoral examination and oral swab were performed on hospitalized individuals at three different times, T1 (within 48 h of hospitalization), T2 (48 h after T1) and T3 (7 days after hospitalization). The oral health status was defined by the Oral Health Assessment Tool (OHAT) and Tongue Coating Status (TCS). The swabs were processed and microorganisms potentially related to nosocomial infections were phenotypically identified through colony morphology, staining and microscopy.
The most prevalent microorganisms were , spp., spp., spp., and . The oral health status was considered median, and the tongue coating index was considered high throughout the study period. The prevalence of potentially pathogenic non-oral microorganisms was high and constant from the first 48 h to the seventh day of hospitalization.
The results point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings, even in patients without mechanical ventilation, thus increasing the risk of nosocomial infections in susceptible individuals. KEY MESSAGESThe present study investigated the oral health status and the presence of pathogenic non-oral microorganisms in the oral cavity of patients hospitalized in the ward, non-intubated and mostly independent of self-care.The presence in the mouth of microorganisms related to the epidemiology of nosocomial infections and resistance to antimicrobials was high and constant from the first 48 h to the 7th day of hospitalization.The results of this study point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings even in patients without mechanical ventilation, increasing the risk of nosocomial infections in susceptible individuals.
描述口腔健康状况，以及在巴西大学医院未插管住院患者的口腔中存在与医院获得性感染和抗微生物药物耐药性相关的潜在非口腔致病性微生物。
在三个不同时间点（入院后 48 小时内（T1）、T1 后 48 小时（T2）和入院后 7 天（T3））对住院个体进行口腔检查和口腔拭子检查。口腔健康状况通过口腔健康评估工具（OHAT）和舌苔状况（TCS）来定义。将拭子进行处理，并通过菌落形态、染色和显微镜观察对可能与医院获得性感染相关的微生物进行表型鉴定。
最常见的微生物是 、 、 、 、 。口腔健康状况被认为是中等的，整个研究期间舌苔指数被认为是高的。从入院的前 48 小时到第 7 天，潜在致病性非口腔微生物的患病率一直很高且保持不变。
研究结果表明，即使在没有机械通气的患者中，口腔也可以作为医院环境中具有流行病学意义的重要病原体的储库，从而增加易感个体发生医院获得性感染的风险。
本研究调查了住院病房、未插管且大多无需自理的患者的口腔健康状况和口腔中致病性非口腔微生物的存在情况。
从入院的前 48 小时到第 7 天，口腔中与医院获得性感染和抗微生物药物耐药性相关的微生物的存在率一直很高且保持不变。
本研究结果表明，即使在没有机械通气的患者中，口腔也可以作为医院环境中具有流行病学意义的重要病原体的储库，从而增加易感个体发生医院获得性感染的风险。
