Abreu de Moraes Daniela, Negrini Lia Érica, Jácome Letícia Maria Tenório, de Azevedo Pedrosa Cunha Carolina, de Freitas Velloso Monte Luciana
Centro Universitário do Distrito Federal, Quadra SEPS 704/904, Asa Sul, 70390-045 Brasília, DF, Brazil.
Faculdade de Ciências da Saúde UNB, Brasília, DF, Brazil.
Heliyon. 2024 Feb 1;10(3):e25241. doi: 10.1016/j.heliyon.2024.e25241. eCollection 2024 Feb 15.
Cystic Fibrosis (CF) is an autosomal recessive disease characterized by the production of thick and viscous mucus progressively affecting various organs and systems, with recurrent respiratory infections. The aim of this study was to learn about the oral health characteristics in CF patients.
Data, such as sociodemographic, general and oral health, were collected from the medical records of CF patients aged 0 to 18 years old. The number of patients with tooth decay, prevalence of developmental defects of enamel (DDE), classification of dental occlusion, sialometry, salivary pH and oral microbial profile and respiratory secretions evaluations were recorded.
Most patients had pancreatic insufficiency (84.2%), malnutrition (60%), respiratory problems (75.4%) and genotyping of the F508del (66.7%). Regarding the medications used, 96.5% used vitamins and electrolyte replacement, 84,02% used pancreatic enzymes, 64.9% used dornase alfa and 47% were using antibiotics. The percentage of patients with tooth decay was 19.3%, 47% had DDE, low salivary flow and basic salivary pH. The most prevalent microorganisms found on tongue biofilm and respiratory secretions were and PA. There was a positive association between the presence of bacteria and fungi found on both the tongue and respiratory secretions. The presence of fungi on the tongue biofilm was significantly associated with the use of antibiotics.
These findings underscore the importance of dentists focusing on prevention and on the specific needs of the patient as well.
囊性纤维化（CF）是一种常染色体隐性疾病，其特征是产生浓稠的黏液，逐渐影响各个器官和系统，并伴有反复的呼吸道感染。本研究的目的是了解CF患者的口腔健康特征。
从0至18岁CF患者的病历中收集社会人口统计学、一般健康状况和口腔健康等数据。记录龋齿患者数量、釉质发育缺陷（DDE）患病率、牙合分类、唾液流量测定、唾液pH值、口腔微生物谱以及呼吸道分泌物评估情况。
大多数患者有胰腺功能不全（84.2%）、营养不良（60%）、呼吸问题（75.4%）以及F508del基因分型（66.7%）。关于所使用的药物，96.5%使用维生素和电解质补充剂，84.02%使用胰酶，64.9%使用多黏菌素，47%正在使用抗生素。龋齿患者的比例为19.3%，47%有DDE，唾液流量低且唾液pH值呈碱性。在舌生物膜和呼吸道分泌物中发现的最常见微生物是[具体微生物名称缺失]和铜绿假单胞菌。在舌和呼吸道分泌物中发现的细菌和真菌之间存在正相关。舌生物膜上真菌的存在与抗生素的使用显著相关。
这些发现强调了牙医关注预防以及患者特殊需求的重要性。
