Ghiasi Zahra, Validad Mohammad Hosein, Ostadkelayeh Shokoufeh Mogharabi, Mazloom Sakineh, Avval Jamshid Ordoni, Moshari Mohammadreza, Dahi Mastaneh, Gharehbeglou Mohammad, Khosravi Mohsen
Department of Psychiatry and Clinical Psychology, School of Medicine, Zahedan University of Medical Sciences, Zahedan.
Department of Ophthalmology, School of Medicine, Zahedan University of Medical Sciences, Zahedan.
Eur J Transl Myol. 2022 Sep 8;33(1):10808. doi: 10.4081/ejtm.2022.10808.
Examination and intervention are always the causes of agitation, anxiety, and fear in children's lives. This study aimed to investigate the effectiveness of promethazine hydrochloride in reducing children's agitation during the ocular examination for trauma. In this interventional-clinical trial study, a total of 62 children referred to Al-Zahra Ophthalmology Hospital in Zahedan, Iran, were evaluated in two matched groups (case (n = 31) and control (n = 31)) for an initial examination of ocular trauma. Finally, the intervention was performed (giving placebo or promethazine hydrochloride cough syrup 20 minutes before the initial ocular examination at 0.5 mg/kg), and the demographic information form and researcher-made questionnaire modeled on the Cohen-Mansfield Agitation Inventory (CMAI) were completed. The obtained results revealed that the mean scores of physical/aggressive behaviors (p ˂ 0.001), physical/nonaggressive behaviors (p = 0.013), verbal/aggressive behaviors (p ˂ 0.001), and hiding behaviors (p ˂ 0.001) were significantly lower in the promethazine hydrochloride-receiving group than the placebo group. These findings demonstrated that promethazine hydrochloride cough syrup facilitated the examination among the pediatric patients who suffered from traumatic ocular injuries. However, further studies in this field need to be carried out through randomized controlled trials.
检查和干预一直是儿童生活中引起躁动、焦虑和恐惧的原因。本研究旨在调查盐酸异丙嗪在减轻儿童眼部创伤检查期间躁动方面的有效性。在这项干预性临床试验研究中，共有62名转诊至伊朗扎黑丹的阿尔扎赫拉眼科医院的儿童，被分为两个匹配组（病例组（n = 31）和对照组（n = 31））进行眼部创伤初步检查评估。最后进行干预（在初次眼部检查前20分钟给予安慰剂或0.5 mg/kg盐酸异丙嗪止咳糖浆），并填写人口统计学信息表和基于科恩-曼斯菲尔德躁动量表（CMAI）编制的研究者问卷。所得结果显示，接受盐酸异丙嗪组的身体/攻击性行为（p ˂ 0.001）、身体/非攻击性行为（p = 0.013）、言语/攻击性行为（p ˂ 0.001）和躲藏行为（p ˂ 0.001）的平均得分显著低于安慰剂组。这些发现表明，盐酸异丙嗪止咳糖浆有助于遭受眼部创伤的儿科患者的检查。然而，该领域需要通过随机对照试验开展进一步研究。
