Zhao Weiwei, Wang Hua, Wang Haimang, Han Ying, Zheng Zhibo, Liu Xudong, Feng Bin, Zhang Hongyu
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Nanoscale. 2021 Apr 7;13(13):6394-6399. doi: 10.1039/d0nr08887k. Epub 2021 Feb 25.
Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.
通过偶氮苯修饰的介孔二氧化硅纳米颗粒（bMSNs-AZO）与β-环糊精修饰的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）（CD-PMPC）之间的超分子相互作用，构建了具有药物递送和润滑增强功能的可见光响应双功能可生物降解介孔二氧化硅纳米颗粒。可见光可有效触发偶氮苯异构化，从而在穿透皮肤组织后诱导药物释放。此外，CD-PMPC在纳米颗粒表面形成的水化层在增强润滑方面发挥了重要作用，这有利于骨关节炎的治疗。
