Department of Mother and Child, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):137-144. doi: 10.47162/RJME.63.1.14.
Endometriosis is a relatively frequent pathology in gynecological practice. We performed an analysis to demonstrate the molecular changes that occur in endometriosis synthetic progestin-treated patients, hoping to sketch a possible pathophysiological pathway that will help us to better understand and treat this debilitating disease. We conducted a prospective study that included a group of 40 women, evaluated in our hospital between 2020-2021. We evaluated immunohistochemical tissue expression of estrogen receptor (ER), progesterone receptor (PR), B-cell lymphoma 2 (Bcl-2) protein, Ki-67, and serum levels of osteopontin (OPN) and vascular endothelial growth factor (VEGF) in patients with ovarian endometrioma with and without progestin treatment. Our study revealed that Desogestrel treatment increases OPN serum levels, PR and Bcl-2 tissue expression and reduces VEGF serum levels and Ki-67 tissue expression. The results we have obtained are very interesting because the serum levels of OPN seem to be more influenced by progestin treatment, than by endometriosis itself. The study we have conducted gives a molecular complex view of what endometriosis represents and on how Desogestrel treatment works.
子宫内膜异位症是妇科临床中较为常见的一种病理。我们进行了一项分析，旨在展示接受合成孕激素治疗的子宫内膜异位症患者发生的分子变化，希望能描绘出一条可能的病理生理学途径，帮助我们更好地理解和治疗这种使人衰弱的疾病。我们进行了一项前瞻性研究，纳入了 2020 年至 2021 年间在我院就诊的 40 名女性。我们评估了卵巢子宫内膜异位症患者的雌激素受体 (ER)、孕激素受体 (PR)、B 细胞淋巴瘤 2 (Bcl-2) 蛋白、Ki-67 的免疫组织化学组织表达以及骨桥蛋白 (OPN) 和血管内皮生长因子 (VEGF) 的血清水平，这些患者接受了孕激素治疗或未接受孕激素治疗。我们的研究表明，地屈孕酮治疗可增加 OPN 的血清水平，增加 PR 和 Bcl-2 的组织表达，降低 VEGF 的血清水平和 Ki-67 的组织表达。我们获得的结果非常有趣，因为 OPN 的血清水平似乎更多地受到孕激素治疗的影响，而不是受子宫内膜异位症本身的影响。我们进行的这项研究从分子角度全面阐述了子宫内膜异位症的本质，以及地屈孕酮的作用机制。
