Church W H, Justice J B, Neill D B
Brain Res. 1987 Jun 2;412(2):397-9. doi: 10.1016/0006-8993(87)91150-4.
A method is described for monitoring extracellular levels of striatal dopamine in the rat during behavior. The extracellular fluid is sampled using a microdialysis probe modified for use in behaving animals. Dopamine concentration in the perfusate is determined every 5 min using an automated smallbore chromatographic system with electrochemical detection. The system is capable of detecting behaviorally related changes of 5 nM, in extracellular dopamine.
描述了一种在大鼠行为过程中监测纹状体多巴胺细胞外水平的方法。使用经过改良的微透析探针采集细胞外液，该探针适用于活动中的动物。每隔5分钟使用配备电化学检测的自动小口径色谱系统测定灌流液中的多巴胺浓度。该系统能够检测细胞外多巴胺中低至5 nM的与行为相关的变化。
