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Constitutional Mosaicism: A Critical Issue in the Definition of BRCA-Inherited Cancer Risk.

作者信息

Tenedini Elena, Piana Simonetta, Toss Angela, Marino Marco, Barbieri Elena, Artuso Lucia, Venturelli Marta, Gasparini Elisa, Mandato Vincenzo Dario, Marchi Isabella, Castellano Sara, Luppi Mario, Trenti Tommaso, Cortesi Laura, Tagliafico Enrico

机构信息

Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics Unit, Modena University Hospital, Modena, Italy.

出版信息

JCO Precis Oncol. 2022 Aug;6:e2200138. doi: 10.1200/PO.22.00138.

DOI:10.1200/PO.22.00138
PMID:36075010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9489180/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b3/9489180/36064d2cd094/po-6-e2200138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b3/9489180/58828eaafe59/po-6-e2200138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b3/9489180/36064d2cd094/po-6-e2200138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b3/9489180/58828eaafe59/po-6-e2200138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89b3/9489180/36064d2cd094/po-6-e2200138-g003.jpg

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The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for Mutations and the Fine Molecular Details of Tumorigenesis.单细胞测序与新一代测序相结合能够揭示突变的嵌合性以及肿瘤发生的精细分子细节。
Cancers (Basel). 2021 May 13;13(10):2354. doi: 10.3390/cancers13102354.
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