Pathak S, Dhaliwal M K, Hopwood V L
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Anticancer Res. 1989 Jan-Feb;9(1):17-9.
We herein propose that specific chromosomal aberrations associated with specific neoplasms are not necessarily inherited as a constitutional trait. High-risk individuals may have a tendency to undergo specific somatic mutations or chromosomal rearrangements at a relatively low frequency in all tissues as mosaicism. This may potentiate the development of specific somatic cancers. Our hypothesis may be applicable to both hereditary and sporadic types of neoplasms.
