Forensic Genetics Research Group, Oslo University Hospital, Oslo, Norway.
Instituto de Ciencias Forenses, Grupo de Medicina Xenómica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Comisaría General de Policía Científica, Laboratorio de ADN, Madrid, Spain.
Forensic Sci Int Genet. 2022 Nov;61:102771. doi: 10.1016/j.fsigen.2022.102771. Epub 2022 Aug 30.
The EuroForMix model has been extended to create a new open-source software called EFMrep which enables the combination of STR DNA mixture samples from different multiplexes. In addition to calculating combined likelihood ratios and carrying out deconvolution, the software also includes the capability to specify related unknown individuals. A graphical user interface has been implemented to ease the analysis for practitioners in real case work. The effect of combining multiple samples based on the PROVEDIt dataset was investigated, either from the same or different multiplexes. The information gain increases when more samples are combined. A head-to-head comparison against EuroForMix shows the benefit of a more general model. Guidelines are provided. A real case example was used to demonstrate how EFMrep could be used to combine multiple samples when a proposition includes kinship.
EuroForMix 模型已经扩展为创建一个新的开源软件，称为 EFMrep，它可以组合来自不同多重分析的 STR DNA 混合样本。除了计算组合似然比和进行反卷积外，该软件还包括指定相关未知个体的能力。已经实现了图形用户界面，以方便实际案例工作中的从业者进行分析。研究了基于 PROVEDIt 数据集的多个样本的组合效果，这些样本来自于相同或不同的多重分析。当组合更多样本时，信息增益会增加。与 EuroForMix 的直接比较显示了更通用模型的优势。提供了指导方针。使用一个实际案例来说明当提议包括亲属关系时，如何使用 EFMrep 组合多个样本。
